| ORD ChicagoUnited States | American Airlines, SkyWest Airlines, United Airlines, Republic Airline | 94 | 599 mi964 km | 2h 15m |
| MCO OrlandoUnited States | American Airlines, Frontier Airlines | 90 | 468 mi753 km | 1h 45m |
| ATL AtlantaUnited States | Delta Air Lines, PSA Airlines, American Airlines | 88 | 226 mi364 km | 1h 14m |
| LGA New YorkUnited States | American Airlines, Endeavor Air, Republic Airline, Frontier Airlines | 87 | 544 mi875 km | 1h 51m |
| BOS BostonUnited States | American Airlines, Republic Airline | 79 | 728 mi1,172 km | 2h 10m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Frontier Airlines | 75 | 935 mi1,505 km | 2h 52m |
| MIA MiamiUnited States | American Airlines, Frontier Airlines | 68 | 650 mi1,046 km | 2h 2m |
| PHL PhiladelphiaUnited States | American Airlines, Frontier Airlines | 66 | 449 mi723 km | 1h 38m |
| BNA NashvilleUnited States | American Airlines, Southwest Airlines, PSA Airlines | 65 | 328 mi528 km | 1h 27m |
| DTW DetroitUnited States | American Airlines, Delta Air Lines | 64 | 500 mi805 km | 1h 43m |
| BWI BaltimoreUnited States | American Airlines, Southwest Airlines, Frontier Airlines, PSA Airlines | 61 | 361 mi581 km | 1h 23m |
| RDU Raleigh/DurhamUnited States | American Airlines | 60 | 130 mi209 km | 54m |
| IAD DullesUnited States | Mesa Airlines, PSA Airlines, American Airlines, GoJet Airlines | 60 | 322 mi518 km | 1h 24m |
| IAH HoustonUnited States | American Airlines, Mesa Airlines, Frontier Airlines, United Airlines | 58 | 912 mi1,468 km | 2h 44m |
| ILM WilmingtonUnited States | Piedmont Airlines, American Airlines | 58 | 185 mi298 km | 1h 2m |
| JFK New YorkUnited States | American Airlines, Endeavor Air | 57 | 542 mi872 km | 1h 56m |
| EWR NewarkUnited States | American Airlines, Republic Airline, United Airlines | 56 | 529 mi851 km | 1h 53m |
| CAE ColumbiaUnited States | Piedmont Airlines | 55 | 88 mi142 km | 58m |
| PHX PhoenixUnited States | American Airlines | 55 | 1,773 mi2,853 km | 4h 24m |
| FLL Fort LauderdaleUnited States | American Airlines, JetBlue, Frontier Airlines | 55 | 632 mi1,017 km | 1h 57m |
| MSP MinneapolisUnited States | Delta Air Lines, American Airlines, Sun Country Airlines | 53 | 930 mi1,497 km | 2h 41m |
| GSO GreensboroUnited States | Piedmont Airlines, American Airlines, Envoy Air, PSA Airlines | 53 | 84 mi135 km | 55m |
| GSP Greenville/Greer/SpartanburgUnited States | Piedmont Airlines, PSA Airlines, Envoy Air | 53 | 75 mi121 km | 54m |
| CHS CharlestonUnited States | American Airlines, PSA Airlines, Piedmont Airlines | 52 | 168 mi270 km | 1h 5m |
| DCA WashingtonUnited States | American Airlines, PSA Airlines | 52 | 331 mi533 km | 1h 28m |
| DEN DenverUnited States | American Airlines, United Airlines, Frontier Airlines | 50 | 1,337 mi2,152 km | 3h 38m |
| SAV SavannahUnited States | PSA Airlines, Piedmont Airlines, American Airlines, Envoy Air | 49 | 213 mi343 km | 1h 11m |
| TYS Knoxville/MaryvilleUnited States | Piedmont Airlines, PSA Airlines, SkyWest Airlines | 48 | 176 mi283 km | 1h 13m |
| CHO CharlottesvilleUnited States | Piedmont Airlines | 48 | 245 mi394 km | 1h 17m |
| TPA TampaUnited States | American Airlines | 48 | 507 mi816 km | 1h 40m |
| LAX Los AngelesUnited States | American Airlines | 48 | 2,125 mi3,420 km | 5h 5m |
| CHA ChattanoogaUnited States | Piedmont Airlines | 47 | 241 mi388 km | 1h 21m |
| MDT HarrisburgUnited States | Piedmont Airlines, PSA Airlines | 47 | 413 mi665 km | 1h 39m |
| ROA RoanokeUnited States | Piedmont Airlines, PSA Airlines | 47 | 155 mi249 km | 1h 13m |
| ORF NorfolkUnited States | American Airlines, PSA Airlines | 47 | 290 mi467 km | 1h 12m |
| RIC RichmondUnited States | American Airlines, PSA Airlines | 46 | 257 mi414 km | 1h 10m |
| TRI BlountvilleUnited States | Piedmont Airlines | 46 | 119 mi192 km | 1h 5m |
| LAS Las VegasUnited States | American Airlines | 41 | 1,916 mi3,084 km | 4h 42m |
| EWN New BernUnited States | Piedmont Airlines | 41 | 222 mi357 km | 1h 11m |
| CMH ColumbusUnited States | American Airlines, PSA Airlines | 40 | 347 mi558 km | 1h 25m |
| STL St LouisUnited States | American Airlines, Southwest Airlines, PSA Airlines | 40 | 575 mi925 km | 1h 55m |
| PIT PittsburghUnited States | American Airlines, PSA Airlines | 40 | 366 mi589 km | 1h 22m |
| YYZ TorontoCanada | American Airlines, PSA Airlines, Jazz Aviation | 39 | 588 mi946 km | 1h 24m |
| AGS AugustaUnited States | Piedmont Airlines | 39 | 140 mi225 km | 1h 6m |
| MYR Myrtle BeachUnited States | American Airlines, PSA Airlines, Piedmont Airlines | 39 | 157 mi253 km | 59m |
| LYH LynchburgUnited States | Piedmont Airlines | 39 | 175 mi282 km | 1h 9m |
| IND IndianapolisUnited States | American Airlines | 39 | 427 mi687 km | 1h 35m |
| FAY FayettevilleUnited States | Piedmont Airlines | 38 | 118 mi190 km | 59m |
| AVL AshevilleUnited States | Piedmont Airlines, PSA Airlines | 37 | 91 mi146 km | 59m |
| LEX LexingtonUnited States | PSA Airlines, Piedmont Airlines | 36 | 281 mi452 km | 1h 23m |
| SEA SeattleUnited States | American Airlines | 34 | 2,279 mi3,668 km | 5h 40m |
| JAX JacksonvilleUnited States | American Airlines | 34 | 328 mi528 km | 1h 20m |
| OAJ RichlandsUnited States | Piedmont Airlines | 34 | 191 mi307 km | 1h 6m |
| MEM MemphisUnited States | American Airlines, PSA Airlines | 34 | 511 mi822 km | 1h 49m |
| CVG Cincinnati / CovingtonUnited States | American Airlines, PSA Airlines | 34 | 335 mi539 km | 1h 27m |
| BDL HartfordUnited States | American Airlines | 34 | 644 mi1,036 km | 1h 51m |
| HSV HuntsvilleUnited States | Piedmont Airlines, PSA Airlines, Envoy Air | 34 | 333 mi536 km | 1h 33m |
| SDF LouisvilleUnited States | PSA Airlines, American Airlines, Piedmont Airlines | 34 | 335 mi539 km | 1h 27m |
| BHM BirminghamUnited States | PSA Airlines, American Airlines, SkyWest Airlines | 33 | 350 mi563 km | 1h 29m |
| CLE ClevelandUnited States | American Airlines | 33 | 430 mi692 km | 1h 36m |
| TLH TallahasseeUnited States | Piedmont Airlines | 33 | 386 mi621 km | 1h 41m |
| SFO San FranciscoUnited States | American Airlines | 32 | 2,296 mi3,695 km | 5h 34m |
| MSY New OrleansUnited States | American Airlines | 31 | 650 mi1,046 km | 1h 58m |
| PNS PensacolaUnited States | PSA Airlines, American Airlines | 30 | 488 mi785 km | 1h 47m |
| LIT Little RockUnited States | Envoy Air, SkyWest Airlines | 30 | 640 mi1,030 km | 2h 14m |
| CAK AkronUnited States | PSA Airlines | 29 | 394 mi634 km | 1h 36m |
| AUS AustinUnited States | American Airlines | 27 | 1,032 mi1,661 km | 2h 53m |
| SAN San DiegoUnited States | American Airlines | 27 | 2,077 mi3,343 km | 4h 59m |
| SAT San AntonioUnited States | American Airlines | 27 | 1,095 mi1,762 km | 2h 55m |
| GNV GainesvilleUnited States | Piedmont Airlines | 27 | 388 mi624 km | 1h 36m |
| PHF Newport NewsUnited States | Piedmont Airlines | 27 | 282 mi454 km | 1h 19m |
| CUN CancúnMexico | American Airlines | 27 | 1,040 mi1,674 km | 2h 54m |
| DAY DaytonUnited States | PSA Airlines, Piedmont Airlines | 27 | 370 mi595 km | 1h 36m |
| PUJ Punta CanaDominican Republic | American Airlines | 27 | 1,381 mi2,223 km | 3h 25m |
| XNA Fayetteville/Springdale/RogersUnited States | PSA Airlines, Envoy Air, American Airlines | 26 | 754 mi1,213 km | 2h 24m |
| PVD Providence/WarwickUnited States | American Airlines | 26 | 684 mi1,101 km | 1h 57m |
| DAB Daytona BeachUnited States | PSA Airlines | 26 | 416 mi669 km | 1h 32m |
| SGF SpringfieldUnited States | PSA Airlines, Envoy Air | 26 | 708 mi1,139 km | 2h 21m |
| VPS ValparaisoUnited States | American Airlines, PSA Airlines | 26 | 460 mi740 km | 1h 43m |
| SBY SalisburyUnited States | Piedmont Airlines | 26 | 371 mi597 km | 1h 33m |
| JAN JacksonUnited States | Piedmont Airlines, PSA Airlines | 26 | 562 mi904 km | 2h 6m |
| ECP Panama City BeachUnited States | PSA Airlines, Envoy Air | 26 | 437 mi703 km | 1h 43m |
| RSW Fort MyersUnited States | American Airlines | 25 | 600 mi966 km | 1h 53m |
| HHH Hilton Head IslandUnited States | Envoy Air | 23 | 206 mi332 km | 1h 11m |
| HPN White PlainsUnited States | PSA Airlines | 23 | 564 mi908 km | 2h 1m |
| NAS NassauBahamas | American Airlines | 21 | 731 mi1,176 km | 2h 15m |
| BUF BuffaloUnited States | American Airlines | 21 | 546 mi879 km | 1h 42m |
| PWM PortlandUnited States | American Airlines | 21 | 813 mi1,308 km | 2h 12m |
| MCI Kansas CityUnited States | American Airlines | 21 | 808 mi1,300 km | 2h 26m |
| LHR LondonUnited Kingdom | American Airlines | 21 | 3,992 mi6,425 km | 7h 46m |
| FWA Fort WayneUnited States | Piedmont Airlines | 21 | 460 mi740 km | 1h 55m |
| GRR Grand RapidsUnited States | American Airlines | 21 | 583 mi938 km | 1h 48m |
| EVV EvansvilleUnited States | Piedmont Airlines | 21 | 414 mi666 km | 1h 48m |
| SRQ Sarasota/BradentonUnited States | American Airlines, PSA Airlines | 21 | 547 mi880 km | 1h 49m |
| ALB AlbanyUnited States | American Airlines | 21 | 646 mi1,040 km | 1h 54m |
| ERI ErieUnited States | Piedmont Airlines | 21 | 475 mi764 km | 1h 48m |
| ROC RochesterUnited States | American Airlines, PSA Airlines | 21 | 573 mi922 km | 1h 45m |
| SYR SyracuseUnited States | American Airlines | 20 | 603 mi970 km | 1h 47m |
| EYW Key WestUnited States | American Airlines, Envoy Air | 20 | 736 mi1,184 km | 2h 12m |
| AVP Wilkes-Barre/ScrantonUnited States | PSA Airlines, American Airlines, Piedmont Airlines | 20 | 509 mi819 km | 1h 45m |
| MHT ManchesterUnited States | PSA Airlines | 20 | 738 mi1,188 km | 2h 11m |
| SLC Salt Lake CityUnited States | American Airlines, Delta Air Lines | 20 | 1,727 mi2,779 km | 4h 24m |
| MLB MelbourneUnited States | PSA Airlines | 20 | 490 mi789 km | 1h 43m |
| PGV GreenvilleUnited States | Piedmont Airlines | 20 | 203 mi327 km | 1h 9m |
| MOB MobileUnited States | Piedmont Airlines | 20 | 526 mi847 km | 1h 58m |
| MSN MadisonUnited States | PSA Airlines, American Airlines | 20 | 708 mi1,139 km | 2h 12m |
| OMA OmahaUnited States | American Airlines | 20 | 913 mi1,469 km | 2h 36m |
| SBN South BendUnited States | PSA Airlines | 19 | 534 mi859 km | 1h 56m |
| MKE MilwaukeeUnited States | American Airlines | 19 | 651 mi1,048 km | 2h 5m |
| GPT GulfportUnited States | Piedmont Airlines, PSA Airlines | 19 | 577 mi929 km | 2h 0m |
| HTS HuntingtonUnited States | Piedmont Airlines | 19 | 235 mi378 km | 1h 14m |
| CRW CharlestonUnited States | PSA Airlines | 18 | 221 mi356 km | 1h 13m |
| MDW ChicagoUnited States | Southwest Airlines | 18 | 584 mi940 km | 1h 53m |
| SJU San JuanPuerto Rico | American Airlines, Frontier Airlines | 18 | 1,475 mi2,374 km | 3h 33m |
| OKC Oklahoma CityUnited States | American Airlines | 18 | 940 mi1,513 km | 2h 40m |
| BTV BurlingtonUnited States | PSA Airlines | 17 | 761 mi1,225 km | 2h 18m |
| SHV ShreveportUnited States | PSA Airlines, SkyWest Airlines, Piedmont Airlines | 15 | 764 mi1,230 km | 2h 32m |
| PLS ProvidencialesTurks and Caicos Islands | American Airlines | 14 | 1,064 mi1,712 km | 2h 51m |
| STT Charlotte AmalieU.S. Virgin Islands | American Airlines | 14 | 1,520 mi2,446 km | 3h 36m |
| MBJ Montego BayJamaica | American Airlines | 14 | 1,165 mi1,875 km | 2h 56m |
| MGM MontgomeryUnited States | Piedmont Airlines | 14 | 372 mi599 km | 1h 37m |
| YUL MontréalCanada | PSA Airlines | 14 | 803 mi1,292 km | 2h 22m |
| MLI MolineUnited States | Piedmont Airlines | 14 | 673 mi1,083 km | 2h 18m |
| MUC MunichGermany | Lufthansa, American Airlines | 14 | 4,579 mi7,369 km | 4h 23m |
| TUL TulsaUnited States | American Airlines | 14 | 842 mi1,355 km | 2h 24m |
| PDX PortlandUnited States | American Airlines | 14 | 2,282 mi3,673 km | 5h 28m |
| FLO FlorenceUnited States | Piedmont Airlines | 13 | 99 mi159 km | 1h 0m |
| DSM Des MoinesUnited States | American Airlines | 13 | 815 mi1,312 km | 2h 25m |
| AUA OranjestadAruba | American Airlines | 13 | 1,706 mi2,746 km | 4h 2m |
| BGR BangorUnited States | American Airlines | 13 | 921 mi1,482 km | 2h 19m |
| PIA PeoriaUnited States | PSA Airlines | 13 | 607 mi977 km | 2h 6m |
| TVC Traverse CityUnited States | PSA Airlines | 13 | 702 mi1,130 km | 2h 12m |
| ABE Allentown/BethlehemUnited States | PSA Airlines | 13 | 481 mi774 km | 1h 45m |
| BTR Baton RougeUnited States | PSA Airlines | 12 | 675 mi1,086 km | 2h 12m |
| MSL Muscle ShoalsUnited States | Contour Airlines | 12 | 379 mi610 km | 1h 41m |
| BKW BeaverUnited States | Contour Airlines | 12 | 178 mi286 km | 1h 11m |
| AOO AltoonaUnited States | Contour Airlines | 11 | 379 mi610 km | 1h 37m |
| PKB Parkersburg (Williamstown)United States | Contour Airlines | 11 | 286 mi460 km | 1h 36m |
| GCM George TownCayman Islands | American Airlines | 7 | 1,096 mi1,764 km | 2h 51m |
| SXM Sint MaartenSint Maarten | American Airlines | 7 | 1,612 mi2,594 km | 3h 58m |
| SHD Weyers CaveUnited States | SkyWest Airlines | 7 | 239 mi385 km | 1h 16m |
| MEX Mexico CityMexico | American Airlines | 7 | 1,551 mi2,496 km | 4h 1m |
| DAL DallasUnited States | Southwest Airlines | 7 | 926 mi1,490 km | 2h 35m |
| FRA Frankfurt am MainGermany | American Airlines | 7 | 4,396 mi7,075 km | 8h 20m |
| LFT LafayetteUnited States | PSA Airlines | 7 | 729 mi1,173 km | 2h 21m |
| MAD MadridSpain | American Airlines | 7 | 4,109 mi6,613 km | 7h 39m |
| SNA Santa AnaUnited States | American Airlines | 7 | 2,099 mi3,378 km | 5h 2m |
| BDA HamiltonBermuda | American Airlines | 7 | 956 mi1,539 km | 2h 30m |
| ELH North EleutheraBahamas | PSA Airlines | 7 | 717 mi1,154 km | 2h 23m |
| DUB DublinIreland | American Airlines | 7 | 3,721 mi5,988 km | 7h 17m |
| MHH Marsh HarbourBahamas | Envoy Air | 7 | 642 mi1,033 km | 2h 6m |
| FCO RomeItaly | American Airlines | 7 | 4,813 mi7,746 km | 9h 5m |
| GGT Moss TownBahamas | PSA Airlines | 7 | 858 mi1,381 km | 2h 35m |
| VRB Vero BeachUnited States | PSA Airlines | 7 | 522 mi840 km | 1h 54m |
| CDG Paris (Roissy-en-France, Val-d'Oise)France | American Airlines | 7 | 4,175 mi6,719 km | 7h 58m |
| JAC JacksonUnited States | American Airlines | 7 | 1,685 mi2,712 km | 4h 7m |
| ATH Spata-ArtemidaGreece | American Airlines | 7 | 5,479 mi8,818 km | 10h 13m |
| AUH Abu DhabiUnited Arab Emirates | Etihad Airways | 7 | 7,407 mi11,920 km | 0m |
| COU ColumbiaUnited States | Envoy Air | 7 | 670 mi1,078 km | 2h 11m |
| LWB LewisburgUnited States | SkyWest Airlines | 7 | 185 mi298 km | 1h 9m |
| SMF SacramentoUnited States | American Airlines | 7 | 2,244 mi3,611 km | 5h 19m |
| ATW AppletonUnited States | PSA Airlines | 7 | 742 mi1,194 km | 2h 19m |
| ONT OntarioUnited States | American Airlines | 7 | 2,078 mi3,344 km | 4h 56m |
| LIR LiberiaCosta Rica | American Airlines | 7 | 1,719 mi2,766 km | 4h 11m |
| CID Cedar RapidsUnited States | American Airlines | 7 | 742 mi1,194 km | 2h 16m |
| SJO San José (Alajuela)Costa Rica | American Airlines | 7 | 1,748 mi2,813 km | 4h 10m |
| UVF Vieux FortSaint Lucia | American Airlines | 7 | 1,934 mi3,112 km | 4h 26m |
| BGI BridgetownBarbados | American Airlines | 7 | 2,029 mi3,265 km | 4h 37m |
| RAP Rapid CityUnited States | PSA Airlines | 7 | 1,322 mi2,128 km | 3h 35m |
| YVR VancouverCanada | American Airlines | 6 | 2,334 mi3,756 km | 5h 28m |
| SJD San José del CaboMexico | American Airlines | 5 | 1,917 mi3,085 km | 4h 47m |
| YYC CalgaryCanada | American Airlines | 5 | 1,973 mi3,175 km | 4h 39m |
| OWB OwensboroUnited States | Contour Airlines | 4 | 387 mi623 km | 1h 49m |
| BZN BozemanUnited States | American Airlines | 4 | 1,736 mi2,794 km | 4h 26m |
| GDL GuadalajaraMexico | Volaris | 3 | 1,694 mi2,726 km | 0m |
| ACK NantucketUnited States | Envoy Air | 3 | 723 mi1,164 km | 2h 15m |
| FPO FreeportBahamas | American Airlines | <1 | 611 mi983 km | 1h 58m |