Busiest flight routes in the US

Nonstop routes ranked by passengers carried in both directions over the last 12 months, August 2025 to July 2026. Only routes still flown regularly in July 2026 are included.

Within the US

#	Route	Passengers (12 months)	Flight time	Flights a week (both ways)	Airlines
1	JFK-LAXNew York and Los Angeles	3,019,745	5h 43m	375	American Airlines, JetBlue Airways, Delta Air Lines
2	LAX-SFOLos Angeles and San Francisco	2,842,155	1h 30m	502	American Airlines, Alaska Airlines, Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
3	LGA-ORDNew York and Chicago	2,736,011	2h 29m	399	American Airlines, Delta Air Lines, United Air Lines, Republic Airline
4	ATL-MCOAtlanta and Orlando	2,696,275	1h 34m	306	Delta Air Lines, Frontier Airlines, Southwest Airlines
5	DEN-PHXDenver and Phoenix	2,417,076	1h 50m	309	American Airlines, Frontier Airlines, United Air Lines, Southwest Airlines
6	LAX-ORDLos Angeles and Chicago	2,332,329	4h 16m	331	American Airlines, Delta Air Lines, Frontier Airlines, United Air Lines
7	ATL-FLLAtlanta and Fort Lauderdale	2,311,630	1h 53m	262	JetBlue Airways, Delta Air Lines, Frontier Airlines
8	HNL-LAXHonolulu, Oahu and Los Angeles	2,260,922	5h 34m	272	American Airlines, Alaska Airlines, Delta Air Lines, United Air Lines, Southwest Airlines
9	LAS-LAXLas Vegas and Los Angeles	2,207,544	1h 12m	300	American Airlines, Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
10	ATL-LGAAtlanta and New York	2,176,270	2h 21m	271	Delta Air Lines, Frontier Airlines, Republic Airline
11	DEN-LAXDenver and Los Angeles	2,042,243	2h 24m	301	Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
12	DEN-LASDenver and Las Vegas	2,039,387	1h 54m	261	Frontier Airlines, United Air Lines, Southwest Airlines
13	ATL-TPAAtlanta and Tampa	1,980,821	1h 30m	243	Delta Air Lines, Frontier Airlines, Southwest Airlines
14	ORD-SFOChicago and San Francisco	1,976,054	4h 32m	232	American Airlines, United Air Lines
15	DEN-ORDDenver and Chicago	1,974,093	2h 40m	242	American Airlines, Frontier Airlines, United Air Lines
16	EWR-MCONewark and Orlando	1,945,587	2h 45m	159	JetBlue Airways, Frontier Airlines, United Air Lines
17	HNL-OGGHonolulu, Oahu and Kahului	1,934,203	43m	364	Alaska Airlines, Lanai Air, Southwest Airlines
18	ATL-DFWAtlanta and Dallas-Fort Worth	1,928,873	2h 16m	258	American Airlines, Delta Air Lines, Frontier Airlines, Envoy Air
19	MCO-ORDOrlando and Chicago	1,924,516	2h 56m	193	American Airlines, Frontier Airlines, United Air Lines
20	DFW-ORDDallas-Fort Worth and Chicago	1,916,229	2h 31m	305	American Airlines, Frontier Airlines, Envoy Air, United Air Lines
21	DFW-LAXDallas-Fort Worth and Los Angeles	1,913,930	3h 9m	251	American Airlines, Delta Air Lines, Frontier Airlines
22	JFK-SFONew York and San Francisco	1,910,892	5h 59m	257	American Airlines, Alaska Airlines, JetBlue Airways, Delta Air Lines
23	ATL-MIAAtlanta and Miami	1,900,965	1h 59m	244	American Airlines, Delta Air Lines, Frontier Airlines, Envoy Air
24	BOS-ORDBoston and Chicago	1,885,442	2h 42m	338	American Airlines, JetBlue Airways, Delta Air Lines, Envoy Air, United Air Lines, Republic Airline
25	DEN-SEADenver and Seattle	1,819,068	2h 49m	305	Alaska Airlines, Delta Air Lines, Frontier Airlines, United Air Lines, Southwest Airlines
26	PHX-SEAPhoenix and Seattle	1,813,154	2h 59m	259	Alaska Airlines, Delta Air Lines, Envoy Air, Southwest Airlines
27	LAX-SEALos Angeles and Seattle	1,810,654	2h 45m	301	American Airlines, Alaska Airlines, Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines
28	LGA-MIANew York and Miami	1,803,016	3h 4m	192	American Airlines, Delta Air Lines
29	DEN-SLCDenver and Salt Lake City	1,799,564	1h 31m	305	Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
30	EWR-LAXNewark and Los Angeles	1,791,699	5h 33m	171	Alaska Airlines, JetBlue Airways, United Air Lines
31	ATL-LAXAtlanta and Los Angeles	1,783,229	4h 28m	189	American Airlines, Delta Air Lines, Frontier Airlines
32	EWR-SFONewark and San Francisco	1,751,765	5h 48m	157	United Air Lines
33	ATL-EWRAtlanta and Newark	1,749,776	2h 17m	210	Delta Air Lines, Frontier Airlines, United Air Lines, Republic Airline
34	DEN-DFWDenver and Dallas-Fort Worth	1,745,260	2h 5m	246	American Airlines, Frontier Airlines, United Air Lines
35	DEN-SFODenver and San Francisco	1,741,805	2h 38m	233	Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
36	EWR-ORDNewark and Chicago	1,731,231	2h 28m	220	American Airlines, United Air Lines
37	DFW-LGADallas-Fort Worth and New York	1,725,756	3h 40m	223	American Airlines, Delta Air Lines, Frontier Airlines
38	DEN-MSPDenver and Minneapolis	1,714,609	2h 1m	271	Delta Air Lines, Frontier Airlines, MN Airlines, United Air Lines, Southwest Airlines
39	IAH-ORDHouston and Chicago	1,710,357	2h 47m	242	American Airlines, Frontier Airlines, United Air Lines, Republic Airline
40	ORD-PHXChicago and Phoenix	1,706,021	3h 40m	187	American Airlines, United Air Lines
41	MCO-PHLOrlando and Philadelphia	1,700,462	2h 34m	182	American Airlines, Frontier Airlines, Southwest Airlines
42	ATL-DENAtlanta and Denver	1,696,826	3h 4m	234	Delta Air Lines, Frontier Airlines, United Air Lines, Southwest Airlines
43	ANC-SEAAnchorage and Seattle	1,694,262	3h 33m	325	Alaska Airlines, Delta Air Lines
44	LAS-SFOLas Vegas and San Francisco	1,682,095	1h 40m	244	Alaska Airlines, Frontier Airlines, United Air Lines, Southwest Airlines
45	DEN-SANDenver and San Diego	1,658,849	2h 22m	242	Alaska Airlines, Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
46	DFW-PHXDallas-Fort Worth and Phoenix	1,646,152	2h 28m	214	American Airlines, Frontier Airlines
47	DEN-IAHDenver and Houston	1,641,385	2h 30m	199	Frontier Airlines, United Air Lines
48	DFW-LASDallas-Fort Worth and Las Vegas	1,630,074	2h 47m	179	American Airlines, Frontier Airlines
49	SEA-SFOSeattle and San Francisco	1,626,788	2h 15m	298	Alaska Airlines, Delta Air Lines, SkyWest Airlines, United Air Lines
50	ATL-LASAtlanta and Las Vegas	1,626,492	4h 3m	175	Delta Air Lines, Frontier Airlines, Southwest Airlines
51	ORD-SEAChicago and Seattle	1,622,704	4h 21m	268	American Airlines, Alaska Airlines, Delta Air Lines, United Air Lines
52	LGA-MCONew York and Orlando	1,605,520	2h 46m	144	American Airlines, JetBlue Airways, Delta Air Lines, Frontier Airlines
53	DFW-MCODallas-Fort Worth and Orlando	1,604,605	2h 49m	196	American Airlines, Frontier Airlines
54	SAN-SFOSan Diego and San Francisco	1,602,478	1h 40m	305	Alaska Airlines, Frontier Airlines, SkyWest Airlines, Horizon Air, United Air Lines, Southwest Airlines
55	LAS-SEALas Vegas and Seattle	1,595,323	2h 36m	220	Alaska Airlines, Delta Air Lines, Frontier Airlines, Southwest Airlines
56	ATL-ORDAtlanta and Chicago	1,591,212	2h 8m	261	American Airlines, Delta Air Lines, Frontier Airlines, United Air Lines, Republic Airline
57	LAS-ORDLas Vegas and Chicago	1,583,952	3h 50m	185	American Airlines, Frontier Airlines, United Air Lines
58	ATL-DTWAtlanta and Detroit	1,581,806	1h 55m	189	Delta Air Lines, Frontier Airlines
59	DFW-SEADallas-Fort Worth and Seattle	1,577,921	4h 5m	226	American Airlines, Alaska Airlines, Delta Air Lines
60	LAX-PHXLos Angeles and Phoenix	1,570,106	1h 26m	283	American Airlines, Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
61	ATL-BOSAtlanta and Boston	1,549,247	2h 40m	205	JetBlue Airways, Delta Air Lines, Frontier Airlines
62	IAH-LAXHouston and Los Angeles	1,543,482	3h 25m	187	Delta Air Lines, Frontier Airlines, SkyWest Airlines, United Air Lines
63	ATL-BWIAtlanta and Baltimore	1,537,950	1h 50m	214	Delta Air Lines, Frontier Airlines, Southwest Airlines
64	DFW-MIADallas-Fort Worth and Miami	1,512,409	3h 2m	182	American Airlines, Frontier Airlines
65	DEN-MCODenver and Orlando	1,493,691	3h 47m	177	Frontier Airlines, United Air Lines, Southwest Airlines
66	ATL-PHLAtlanta and Philadelphia	1,474,196	2h 6m	236	American Airlines, Delta Air Lines, Frontier Airlines, PSA Airlines
67	LAS-PHXLas Vegas and Phoenix	1,471,575	1h 8m	222	American Airlines, Frontier Airlines, SkyWest Airlines, Southwest Airlines
68	BOS-DCABoston and Washington	1,456,826	1h 42m	307	American Airlines, JetBlue Airways, Envoy Air, Republic Airline
69	HNL-LIHHonolulu, Oahu and Lihue, Kauai	1,448,912	42m	299	Alaska Airlines, Southwest Airlines
70	PHX-SANPhoenix and San Diego	1,445,059	1h 17m	265	American Airlines, Frontier Airlines, SkyWest Airlines, Horizon Air, Southwest Airlines
71	CLT-MCOCharlotte and Orlando	1,438,726	1h 46m	180	American Airlines, Frontier Airlines
72	JFK-MCONew York and Orlando	1,429,589	2h 47m	158	JetBlue Airways, Delta Air Lines
73	ATL-IAHAtlanta and Houston	1,429,437	2h 9m	197	Delta Air Lines, Frontier Airlines, United Air Lines, Mesa Airlines
74	BOS-SFOBoston and San Francisco	1,385,387	6h 5m	222	JetBlue Airways, Delta Air Lines, United Air Lines
75	HNL-KOAHonolulu, Oahu and Kailua-Kona	1,385,371	50m	269	Alaska Airlines, Southwest Airlines
76	FLL-LGAFort Lauderdale and New York	1,383,763	2h 59m	143	American Airlines, JetBlue Airways, Delta Air Lines
77	EWR-FLLNewark and Fort Lauderdale	1,376,885	2h 59m	122	JetBlue Airways, United Air Lines
78	BOS-MCOBoston and Orlando	1,360,611	3h 7m	150	American Airlines, JetBlue Airways, Delta Air Lines, Frontier Airlines
79	ATL-DCAAtlanta and Washington	1,357,960	1h 50m	240	Delta Air Lines, Envoy Air, PSA Airlines, Southwest Airlines, Republic Airline
80	ATL-RDUAtlanta and Raleigh/Durham	1,340,336	1h 24m	181	Delta Air Lines, Frontier Airlines
81	JFK-MIANew York and Miami	1,326,429	3h 4m	156	American Airlines, Delta Air Lines
82	MIA-ORDMiami and Chicago	1,320,953	3h 18m	148	American Airlines, United Air Lines
83	HNL-ITOHonolulu, Oahu and Hilo	1,316,925	56m	233	Alaska Airlines, Southwest Airlines
84	DFW-SFODallas-Fort Worth and San Francisco	1,313,224	3h 39m	187	American Airlines, Frontier Airlines, United Air Lines
85	DEN-PDXDenver and Portland	1,297,839	2h 35m	205	Alaska Airlines, Frontier Airlines, United Air Lines, Southwest Airlines
86	LAS-SANLas Vegas and San Diego	1,296,112	1h 19m	248	Frontier Airlines, SkyWest Airlines, Horizon Air, Southwest Airlines
87	ATL-JAXAtlanta and Jacksonville	1,294,077	1h 10m	172	Delta Air Lines, Frontier Airlines
88	DCA-ORDWashington and Chicago	1,290,949	2h 9m	274	American Airlines, SkyWest Airlines, United Air Lines, Republic Airline
89	AUS-DENAustin and Denver	1,286,193	2h 13m	239	Frontier Airlines, SkyWest Airlines, United Air Lines, Southwest Airlines
90	DEN-LGADenver and New York	1,284,953	4h 2m	164	Delta Air Lines, United Air Lines, Southwest Airlines
91	PHX-SLCPhoenix and Salt Lake City	1,273,233	1h 38m	201	Delta Air Lines, Frontier Airlines, Envoy Air, SkyWest Airlines, Southwest Airlines
92	DTW-MCODetroit and Orlando	1,269,250	2h 40m	119	Delta Air Lines, Frontier Airlines
93	BOS-LAXBoston and Los Angeles	1,267,378	5h 53m	212	American Airlines, JetBlue Airways, Delta Air Lines, United Air Lines
94	ATL-AUSAtlanta and Austin	1,265,469	2h 17m	175	Delta Air Lines, Frontier Airlines, Southwest Airlines
95	MSP-ORDMinneapolis and Chicago	1,254,660	1h 39m	260	American Airlines, Delta Air Lines, Envoy Air, SkyWest Airlines, MN Airlines, United Air Lines, Republic Airline
96	DFW-IAHDallas-Fort Worth and Houston	1,254,131	1h 19m	234	American Airlines, Envoy Air, SkyWest Airlines, United Air Lines, Mesa Airlines
97	ATL-JFKAtlanta and New York	1,252,807	2h 23m	149	JetBlue Airways, Delta Air Lines, Frontier Airlines
98	ORD-PHLChicago and Philadelphia	1,241,526	2h 16m	205	American Airlines, Frontier Airlines, United Air Lines
99	BWI-MCOBaltimore and Orlando	1,235,645	2h 16m	167	Frontier Airlines, Southwest Airlines
100	SAN-SEASan Diego and Seattle	1,233,375	2h 54m	205	Alaska Airlines, Delta Air Lines, Southwest Airlines

Between the US and other countries

#	Route	Passengers (12 months)	Flight time	Flights a week (both ways)	Airlines
1	JFK-LHRNew York and London	2,984,474	2h 40m	275	American Airlines, JetBlue Airways, British Airways, Delta Air Lines, Virgin Atlantic Airways
2	MCO-SJUOrlando and San Juan	1,937,103	2h 57m	286	JetBlue Airways, Frontier Airlines, Southwest Airlines
3	CDG-JFKParis (Roissy-en-France, Val-d'Oise) and New York	1,658,571	3h 28m	150	American Airlines, Compagnie Natl Air France, JetBlue Airways, Delta Air Lines
4	LAX-LHRLos Angeles and London	1,410,748	3h 51m	119	American Airlines, British Airways, United Air Lines, Virgin Atlantic Airways
5	SFO-TPESan Francisco and Taoyuan	1,253,719	3h 31m	92	Eva Airways Corporation, China Airlines, STARLUX AIRLINES, United Air Lines
6	HND-LAXTokyo and Los Angeles	1,162,677	6h 9m	98	American Airlines, Delta Air Lines, Japan Air Lines, All Nippon Airways, United Air Lines
7	JFK-SJUNew York and San Juan	1,142,025	3h 56m	128	JetBlue Airways, Delta Air Lines
8	BOS-LHRBoston and London	1,082,640	2h 50m	111	American Airlines, JetBlue Airways, British Airways, Delta Air Lines, Virgin Atlantic Airways
9	LGA-YYZNew York and Toronto	1,049,765	49m	239	Endeavor Air, Air Canada, Jazz Aviation, Republic Airline
10	LHR-MIALondon and Miami	1,048,211	2h 45m	63	American Airlines, British Airways, Virgin Atlantic Airways
11	LHR-SFOLondon and San Francisco	1,040,938	4h 35m	97	British Airways, United Air Lines, Virgin Atlantic Airways
12	LHR-ORDLondon and Chicago	1,036,729	5h 48m	119	American Airlines, British Airways, United Air Lines
13	GDL-LAXGuadalajara and Los Angeles	1,033,590	30m	111	Alaska Airlines, VivaAerobus, Concesionaria Vuela Compania De Aviacion
14	JFK-STINew York and Santiago	1,030,893	3h 43m	140	JetBlue Airways, Delta Air Lines
15	ICN-LAXSeoul and Los Angeles	1,003,046	0m	56	Korean Air Lines, Asiana Airlines
16	FCO-JFKRome and New York	982,270	4h 12m	56	American Airlines, Delta Air Lines, Norse Atlantic AirwaysAS
17	CUN-DFWCancún and Dallas-Fort Worth	977,945	2h 53m	126	American Airlines, Frontier Airlines, MN Airlines
18	EWR-LHRNewark and London	974,691	5h 58m	120	British Airways, United Air Lines
19	BOG-MIABogota and Miami	965,167	1h 4m	123	Aerovias de Intergracian Regional, American Airlines, Aerovias Nacl De Colombia
20	HND-HNLTokyo and Honolulu, Oahu	954,689	4h 2m	84	Alaska Airlines, Delta Air Lines, Japan Air Lines, All Nippon Airways
21	LAX-TPELos Angeles and Taoyuan	940,307	0m	66	Eva Airways Corporation, China Airlines, STARLUX AIRLINES
22	JFK-SDQNew York and Santo Domingo	921,586	3h 53m	125	JetBlue Airways, Delta Air Lines
23	CDG-LAXParis (Roissy-en-France, Val-d'Oise) and Los Angeles	915,720	1h 44m	69	Compagnie Natl Air France, Delta Air Lines
24	HKG-SFOHong Kong and San Francisco	913,339	6h 8m	55	Cathay Pacific Airways, United Air Lines
25	HKG-LAXHong Kong and Los Angeles	910,783	6h 6m	83	Cathay Pacific Airways, Delta Air Lines, United Air Lines
26	MIA-SJUMiami and San Juan	900,726	2h 42m	98	American Airlines, Frontier Airlines
27	ORD-YYZChicago and Toronto	898,079	1h 24m	230	Air Canada, Envoy Air, SkyWest Airlines, Jazz Aviation, United Air Lines, Republic Airline
28	LAX-MEXLos Angeles and Mexico City	878,575	30m	54	American Airlines, VivaAerobus, Concesionaria Vuela Compania De Aviacion
29	GRU-MIASão Paulo and Miami	867,506	4h 33m	59	American Airlines, Latam Airlines Brasil
30	EZE-MIABuenos Aires (Ezeiza) and Miami	865,991	4h 52m	80	American Airlines, Aerolineas Argentinas, Lan Airlines
31	DFW-LHRDallas-Fort Worth and London	856,971	8h 5m	69	American Airlines, British Airways
32	LIM-MIALima and Miami	842,206	2h 41m	88	American Airlines, Sky Airline Peru, Lan Peru Airlines
33	MIA-PTYMiami and Tocumen	829,182	30m	121	American Airlines, Compania Panamena (Copa)
34	IAH-MEXHouston and Mexico City	828,418	1h 22m	104	United Air Lines, VivaAerobus, Concesionaria Vuela Compania De Aviacion
35	ICN-JFKSeoul and New York	823,787	0m	56	Korean Air Lines, Asiana Airlines
36	IAD-LHRDulles and London	800,971	2h 52m	80	British Airways, United Air Lines, Virgin Atlantic Airways
37	CUN-ORDCancún and Chicago	798,030	3h 53m	78	American Airlines, Frontier Airlines, United Air Lines
38	JFK-MADNew York and Madrid	789,701	3h 20m	70	American Airlines, Delta Air Lines, Iberia Air Lines Of Spain, Air Europa
39	AMS-ATLAmsterdam and Atlanta	780,102	5h 47m	56	Delta Air Lines, Klm Royal Dutch Airlines
40	SEA-TPESeattle and Taoyuan	770,547	2h 49m	55	Eva Airways Corporation, China Airlines, Delta Air Lines, STARLUX AIRLINES
41	LAX-NRTLos Angeles and Narita	763,610	2h 11m	60	Japan Air Lines, All Nippon Airways, United Air Lines, ZIPAIR Tokyo
42	SFO-YVRSan Francisco and Vancouver	763,049	1h 9m	131	Flair Airlines, Air Canada, Jazz Aviation, Air Canada rouge, United Air Lines
43	HNL-NRTHonolulu, Oahu and Narita	762,696	0m	47	Japan Air Lines, All Nippon Airways, ZIPAIR Tokyo
44	ATL-CDGAtlanta and Paris (Roissy-en-France, Val-d'Oise)	759,736	4h 47m	68	Compagnie Natl Air France, Delta Air Lines
45	ATL-LHRAtlanta and London	756,478	5h 15m	69	British Airways, Delta Air Lines, Virgin Atlantic Airways
46	MEX-ORDMexico City and Chicago	745,107	1h 12m	70	American Airlines, United Air Lines, VivaAerobus, Concesionaria Vuela Compania De Aviacion
47	ATL-SJUAtlanta and San Juan	739,694	3h 43m	79	Delta Air Lines, Frontier Airlines
48	LAX-SYDLos Angeles and Sydney (Mascot)	739,381	10h 58m	54	American Airlines, Delta Air Lines, Qantas Airways, United Air Lines
49	LAX-YVRLos Angeles and Vancouver	737,226	50m	114	Flair Airlines, American Airlines, Air Canada, Air Canada rouge, United Air Lines, Westjet
50	AMS-JFKAmsterdam and New York	734,718	3h 51m	55	Delta Air Lines, Klm Royal Dutch Airlines
51	ATL-CUNAtlanta and Cancún	732,114	2h 37m	86	Delta Air Lines, Frontier Airlines, Southwest Airlines
52	MAD-MIAMadrid and Miami	723,250	2h 36m	55	American Airlines, Iberia Air Lines Of Spain, Air Europa
53	MCO-YYZOrlando and Toronto	716,450	0m	59	Air Canada rouge, Westjet
54	HND-JFKTokyo and New York	712,071	2h 38m	69	American Airlines, Japan Air Lines, All Nippon Airways
55	FRA-ORDFrankfurt am Main and Chicago	709,726	4h 36m	55	Lufthansa German Airlines, United Air Lines
56	ICN-SFOSeoul and San Francisco	708,082	5h 32m	56	Korean Air Lines, Asiana Airlines, United Air Lines
57	MEX-MIAMexico City and Miami	697,850	1h 34m	56	American Airlines, Concesionaria Vuela Compania De Aviacion
58	FLL-YYZFort Lauderdale and Toronto	689,607	0m	41	Flair Airlines, Air Canada rouge, Westjet
59	FLL-SJUFort Lauderdale and San Juan	688,564	2h 37m	96	JetBlue Airways, Frontier Airlines
60	EWR-SJUNewark and San Juan	682,556	4h 1m	78	JetBlue Airways, United Air Lines
61	CUN-IAHCancún and Houston	669,376	2h 23m	98	Frontier Airlines, United Air Lines
62	JFK-PUJNew York and Punta Cana	653,375	3h 57m	80	American Airlines, JetBlue Airways, Delta Air Lines
63	CUN-JFKCancún and New York	647,999	4h 1m	67	American Airlines, JetBlue Airways, Delta Air Lines
64	ICN-SEASeoul and Seattle	642,290	5h 19m	50	Alaska Airlines, Delta Air Lines, Korean Air Lines, Asiana Airlines
65	PHL-SJUPhiladelphia and San Juan	641,449	3h 58m	79	American Airlines, JetBlue Airways, Frontier Airlines
66	IAH-SALHouston and San Salvador (San Luis Talpa)	641,161	1h 53m	89	Vuela EL Salvador, Taca International Airlines, United Air Lines
67	DFW-MEXDallas-Fort Worth and Mexico City	630,559	1h 53m	82	American Airlines, Concesionaria Vuela Compania De Aviacion
68	LAX-SALLos Angeles and San Salvador (San Luis Talpa)	629,430	56m	80	Vuela EL Salvador, Taca International Airlines, United Air Lines
69	FRA-IADFrankfurt am Main and Dulles	626,418	4h 52m	54	Lufthansa German Airlines, United Air Lines
70	SEA-YVRSeattle and Vancouver	626,402	51m	234	SkyWest Airlines, Jazz Aviation, Horizon Air
71	JFK-MEXNew York and Mexico City	624,957	1h 57m	41	American Airlines, Delta Air Lines, VivaAerobus
72	JFK-MXPNew York and Ferno (VA)	622,692	5h 37m	39	American Airlines, Delta Air Lines, Neos S.P.A
73	MIA-SDQMiami and Santo Domingo	620,865	1h 59m	84	American Airlines, Arajet
74	MCO-PTYOrlando and Tocumen	617,672	0m	90	Compania Panamena (Copa)
75	IAD-SALDulles and San Salvador (San Luis Talpa)	616,211	22m	90	Vuela EL Salvador, Taca International Airlines, United Air Lines
76	IST-JFKIstanbul and New York	615,399	0m	50	Turk Hava Yollari A.O.
77	NRT-SFONarita and San Francisco	606,170	2h 34m	56	Japan Air Lines, All Nippon Airways, United Air Lines, ZIPAIR Tokyo
78	DUB-JFKDublin and New York	605,294	2h 37m	65	JetBlue Airways, Delta Air Lines, Aer Lingus
79	FRA-SFOFrankfurt am Main and San Francisco	601,695	6h 53m	42	Lufthansa German Airlines, United Air Lines
80	MNL-SFOManila (Pasay) and San Francisco	599,403	8h 50m	41	Philippine Airlines, United Air Lines
81	HKG-JFKHong Kong and New York	598,888	0m	40	Cathay Pacific Airways
82	ATL-ICNAtlanta and Seoul	578,654	8h 45m	56	Delta Air Lines, Korean Air Lines
83	LHR-SEALondon and Seattle	563,864	3h 9m	69	Alaska Airlines, British Airways, Delta Air Lines, Virgin Atlantic Airways
84	JFK-TLVNew York and Tel Aviv	563,394	2h 15m	46	El Al Israel Airlines
85	GRU-JFKSão Paulo and New York	543,035	6h 27m	42	American Airlines, Delta Air Lines, Latam Airlines Brasil
86	SFO-YYZSan Francisco and Toronto	542,204	1h 47m	82	Air Canada, United Air Lines
87	FRA-JFKFrankfurt am Main and New York	540,834	1h 43m	41	Delta Air Lines, Lufthansa German Airlines
88	LAX-SJDLos Angeles and San José del Cabo	536,241	2h 29m	78	American Airlines, Alaska Airlines, Delta Air Lines, United Air Lines
89	BOS-SJUBoston and San Juan	536,111	4h 4m	53	JetBlue Airways, Delta Air Lines
90	BOS-CDGBoston and Paris (Roissy-en-France, Val-d'Oise)	532,106	4h 15m	56	Compagnie Natl Air France, JetBlue Airways, Delta Air Lines
91	EWR-SDQNewark and Santo Domingo	528,941	2h 52m	72	JetBlue Airways, Arajet, United Air Lines
92	CUN-LAXCancún and Los Angeles	525,245	4h 52m	66	American Airlines, Delta Air Lines, United Air Lines
93	EWR-YYZNewark and Toronto	521,674	52m	136	Air Canada, Jazz Aviation, Republic Airline
94	BCN-JFKBarcelona and New York	519,797	4h 42m	40	American Airlines, Delta Air Lines, LEVEL
95	LAX-YYZLos Angeles and Toronto	515,535	0m	55	Air Canada
96	AMS-MSPAmsterdam and Minneapolis	513,598	7h 39m	50	Delta Air Lines, Klm Royal Dutch Airlines
97	FLL-YULFort Lauderdale and Montréal	512,606	0m	26	Air Canada rouge
98	SFO-SINSan Francisco and Singapore	511,465	11h 20m	28	United Air Lines
99	IAH-LHRHouston and London	510,582	5h 15m	55	British Airways, United Air Lines
100	MIA-PUJMiami and Punta Cana	506,664	1h 54m	91	American Airlines, Arajet, Frontier Airlines, Lan Airlines

Source: US Department of Transportation, T-100 Segment data. Covers every airline flying within, to or from the US; routes between two other countries are not included.