| ATL AtlantaUnited States | Delta Air Lines, American Airlines, Frontier Airlines, Envoy Air | 122 | 594 mi956 km | 2h 2m |
| LGA New YorkUnited States | American Airlines, Delta Air Lines | 96 | 1,096 mi1,764 km | 2h 58m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Frontier Airlines | 91 | 1,121 mi1,804 km | 3h 18m |
| JFK New YorkUnited States | American Airlines, Delta Air Lines | 78 | 1,089 mi1,753 km | 2h 59m |
| ORD ChicagoUnited States | American Airlines, United Airlines | 74 | 1,197 mi1,926 km | 3h 29m |
| CLT CharlotteUnited States | American Airlines, Frontier Airlines | 72 | 650 mi1,046 km | 2h 7m |
| DCA WashingtonUnited States | American Airlines, Delta Air Lines | 71 | 919 mi1,479 km | 2h 32m |
| PHL PhiladelphiaUnited States | American Airlines, Frontier Airlines | 68 | 1,013 mi1,630 km | 2h 47m |
| IAH HoustonUnited States | American Airlines, United Airlines, Frontier Airlines | 63 | 964 mi1,551 km | 2h 52m |
| LAX Los AngelesUnited States | American Airlines, Delta Air Lines | 63 | 2,342 mi3,769 km | 5h 35m |
| BOG BogotaColombia | Avianca, American Airlines, LATAM Airlines Colombia | 62 | 1,506 mi2,424 km | 1h 2m |
| MCO OrlandoUnited States | American Airlines, Southwest Airlines | 61 | 192 mi309 km | 1h 11m |
| PTY TocumenPanama | Copa Airlines, American Airlines | 61 | 1,152 mi1,854 km | 30m |
| BOS BostonUnited States | American Airlines, Delta Air Lines | 58 | 1,258 mi2,025 km | 3h 18m |
| EWR NewarkUnited States | United Airlines, American Airlines | 56 | 1,085 mi1,746 km | 3h 2m |
| TPA TampaUnited States | American Airlines, Envoy Air | 52 | 204 mi328 km | 1h 5m |
| RDU Raleigh/DurhamUnited States | American Airlines, Delta Air Lines, Envoy Air, Frontier Airlines | 51 | 700 mi1,127 km | 2h 10m |
| SJU San JuanPuerto Rico | American Airlines, Frontier Airlines | 49 | 1,045 mi1,682 km | 2h 34m |
| HAV HavanaCuba | American Airlines, Delta Air Lines | 49 | 235 mi378 km | 1h 15m |
| BNA NashvilleUnited States | American Airlines, Southwest Airlines, Envoy Air, Republic Airline | 47 | 806 mi1,297 km | 2h 24m |
| AUS AustinUnited States | American Airlines, Delta Air Lines, Southwest Airlines | 47 | 1,103 mi1,775 km | 3h 5m |
| PUJ Punta CanaDominican Republic | American Airlines, Frontier Airlines, Arajet, LATAM Airlines | 45 | 911 mi1,466 km | 1h 50m |
| LIM LimaPeru | American Airlines, LATAM Airlines Perú, Sky Airline Peru | 44 | 2,608 mi4,197 km | 2h 39m |
| SDQ Santo DomingoDominican Republic | American Airlines, Arajet | 42 | 848 mi1,365 km | 1h 55m |
| DEN DenverUnited States | American Airlines, United Airlines, Frontier Airlines, Southwest Airlines | 42 | 1,709 mi2,750 km | 4h 26m |
| NAS NassauBahamas | American Airlines | 42 | 185 mi298 km | 1h 1m |
| EZE Buenos Aires (Ezeiza)Argentina | American Airlines, AerolÃneas Argentinas, LATAM Airlines | 40 | 4,406 mi7,091 km | 4h 50m |
| SFO San FranciscoUnited States | American Airlines, United Airlines | 40 | 2,585 mi4,160 km | 6h 12m |
| BWI BaltimoreUnited States | Southwest Airlines, American Airlines, Frontier Airlines | 40 | 946 mi1,522 km | 2h 34m |
| MDE MedellÃnColombia | American Airlines, Avianca | 35 | 1,388 mi2,234 km | 1h 50m |
| PHX PhoenixUnited States | American Airlines | 34 | 1,972 mi3,174 km | 4h 53m |
| LAS Las VegasUnited States | American Airlines, Frontier Airlines | 34 | 2,174 mi3,499 km | 5h 16m |
| LHR LondonUnited Kingdom | British Airways, Virgin Atlantic, American Airlines | 31 | 4,425 mi7,121 km | 2h 37m |
| GRU São PauloBrazil | LATAM Airlines Brasil, American Airlines | 30 | 4,072 mi6,553 km | 4h 34m |
| EIS Beef IslandBritish Virgin Islands | Envoy Air | 29 | 1,128 mi1,815 km | 2h 48m |
| JAX JacksonvilleUnited States | Envoy Air, American Airlines | 28 | 335 mi539 km | 1h 23m |
| MEX Mexico CityMexico | American Airlines, Volaris | 28 | 1,276 mi2,054 km | 1h 38m |
| MGA ManaguaNicaragua | American Airlines, Avianca El Salvador | 28 | 1,014 mi1,632 km | 1h 16m |
| SEA SeattleUnited States | American Airlines, Alaska Airlines, Delta Air Lines | 28 | 2,724 mi4,384 km | 6h 40m |
| TLH TallahasseeUnited States | Envoy Air | 28 | 402 mi647 km | 1h 31m |
| SJO San José (Alajuela)Costa Rica | American Airlines, Avianca Costa Rica | 28 | 1,117 mi1,798 km | 2h 2m |
| MSY New OrleansUnited States | American Airlines | 28 | 674 mi1,085 km | 2h 8m |
| MAD MadridSpain | Iberia, American Airlines, Air Europa | 28 | 4,424 mi7,120 km | 2h 27m |
| CUN CancúnMexico | American Airlines | 26 | 531 mi855 km | 1h 44m |
| CMH ColumbusUnited States | Envoy Air, Southwest Airlines, Republic Airline | 26 | 990 mi1,593 km | 2h 47m |
| YYZ TorontoCanada | Air Canada Rouge, American Airlines | 25 | 1,233 mi1,984 km | 1h 7m |
| SAL San Salvador (San Luis Talpa)El Salvador | American Airlines, Avianca El Salvador | 25 | 1,023 mi1,646 km | 1h 26m |
| STL St LouisUnited States | Southwest Airlines, American Airlines, Envoy Air | 23 | 1,068 mi1,719 km | 2h 53m |
| DTW DetroitUnited States | Delta Air Lines, American Airlines, Envoy Air | 22 | 1,145 mi1,843 km | 3h 7m |
| MSP MinneapolisUnited States | Delta Air Lines, American Airlines | 22 | 1,501 mi2,416 km | 3h 55m |
| EYW Key WestUnited States | Envoy Air, Republic Airline | 21 | 126 mi203 km | 58m |
| PNS PensacolaUnited States | Envoy Air | 21 | 530 mi853 km | 1h 53m |
| POS Port of SpainTrinidad and Tobago | American Airlines, Caribbean Airlines | 21 | 1,622 mi2,610 km | 2h 16m |
| KIN KingstonJamaica | American Airlines | 21 | 586 mi943 km | 1h 45m |
| AUA OranjestadAruba | American Airlines | 21 | 1,133 mi1,823 km | 2h 54m |
| MHH Marsh HarbourBahamas | Envoy Air | 21 | 205 mi330 km | 1h 3m |
| GGT Moss TownBahamas | Envoy Air | 21 | 317 mi510 km | 1h 13m |
| ELH North EleutheraBahamas | Envoy Air | 21 | 226 mi364 km | 1h 5m |
| PLS ProvidencialesTurks and Caicos Islands | American Airlines | 21 | 578 mi930 km | 1h 49m |
| BAQ BarranquillaColombia | American Airlines, Avianca | 21 | 1,087 mi1,749 km | 2h 4m |
| CLO CaliColombia | American Airlines, Avianca | 21 | 1,552 mi2,498 km | 3h 10m |
| CHS CharlestonUnited States | American Airlines | 21 | 489 mi787 km | 1h 46m |
| MCI Kansas CityUnited States | American Airlines, Southwest Airlines, Envoy Air | 21 | 1,251 mi2,013 km | 3h 22m |
| UIO QuitoEcuador | American Airlines, LATAM Airlines Ecuador | 20 | 1,787 mi2,876 km | 2h 43m |
| GYE GuayaquilEcuador | American Airlines, Avianca Ecuador | 20 | 1,922 mi3,093 km | 2h 52m |
| YUL MontréalCanada | Air Canada, American Airlines, Air Canada Rouge | 19 | 1,404 mi2,260 km | 49m |
| CLE ClevelandUnited States | American Airlines, Envoy Air, Frontier Airlines | 19 | 1,080 mi1,738 km | 3h 0m |
| GUA Guatemala CityGuatemala | American Airlines | 19 | 1,017 mi1,637 km | 2h 38m |
| SLC Salt Lake CityUnited States | American Airlines, Delta Air Lines | 19 | 2,088 mi3,360 km | 5h 13m |
| SCL SantiagoChile | LATAM Airlines, American Airlines | 18 | 4,118 mi6,627 km | 3h 19m |
| BSB BrasÃliaBrazil | Gol Linhas Aéreas | 16 | 3,599 mi5,792 km | 0m |
| STT Charlotte AmalieU.S. Virgin Islands | American Airlines | 15 | 1,107 mi1,782 km | 2h 44m |
| GSP Greenville/Greer/SpartanburgUnited States | Envoy Air, Republic Airline | 15 | 637 mi1,025 km | 2h 1m |
| PIT PittsburghUnited States | American Airlines | 15 | 1,013 mi1,630 km | 2h 44m |
| AXA The ValleyAnguilla | Envoy Air | 15 | 1,221 mi1,965 km | 2h 59m |
| CVG Cincinnati / CovingtonUnited States | Envoy Air | 14 | 948 mi1,526 km | 2h 47m |
| GCM George TownCayman Islands | American Airlines | 14 | 453 mi729 km | 1h 2m |
| IND IndianapolisUnited States | American Airlines | 14 | 1,020 mi1,642 km | 2h 51m |
| SXM Sint MaartenSint Maarten | American Airlines | 14 | 1,224 mi1,970 km | 3h 4m |
| BGI BridgetownBarbados | American Airlines | 14 | 1,611 mi2,593 km | 3h 37m |
| MBJ Montego BayJamaica | American Airlines | 14 | 524 mi843 km | 1h 42m |
| CUR WillemstadCuraçao | American Airlines | 14 | 1,192 mi1,918 km | 2h 57m |
| CDG Paris (Roissy-en-France, Val-d'Oise)France | Air France | 14 | 4,589 mi7,385 km | 1h 8m |
| LIR LiberiaCosta Rica | American Airlines | 14 | 1,101 mi1,772 km | 2h 55m |
| STX ChristianstedU.S. Virgin Islands | American Airlines | 14 | 1,139 mi1,833 km | 2h 44m |
| FPO FreeportBahamas | Envoy Air | 14 | 112 mi180 km | 52m |
| SAN San DiegoUnited States | American Airlines | 14 | 2,267 mi3,648 km | 5h 28m |
| STI SantiagoDominican Republic | American Airlines | 14 | 759 mi1,221 km | 2h 7m |
| ORF NorfolkUnited States | American Airlines | 14 | 802 mi1,291 km | 2h 18m |
| ANU OsbournAntigua and Barbuda | American Airlines | 14 | 1,330 mi2,140 km | 3h 13m |
| IST IstanbulTurkey | Turkish Airlines | 14 | 5,966 mi9,601 km | 0m |
| XPL PalmerolaHonduras | American Airlines | 14 | 918 mi1,477 km | 2h 32m |
| CTG CartagenaColombia | American Airlines | 14 | 1,101 mi1,772 km | 2h 41m |
| BHM BirminghamUnited States | Envoy Air | 14 | 661 mi1,064 km | 2h 5m |
| POP Puerto PlataDominican Republic | American Airlines | 14 | 746 mi1,201 km | 2h 8m |
| SAP San Pedro SulaHonduras | American Airlines | 14 | 866 mi1,394 km | 1h 56m |
| BZE Belize CityBelize | American Airlines | 14 | 767 mi1,234 km | 2h 18m |
| SAV SavannahUnited States | Envoy Air | 12 | 440 mi708 km | 1h 35m |
| RIC RichmondUnited States | American Airlines | 12 | 826 mi1,329 km | 2h 23m |
| GSO GreensboroUnited States | Envoy Air | 12 | 710 mi1,143 km | 2h 14m |
| MTY MonterreyMexico | Envoy Air, Viva | 12 | 1,234 mi1,986 km | 2h 18m |
| BCN BarcelonaSpain | American Airlines, Level | 11 | 4,697 mi7,559 km | 5h 15m |
| LIS LisbonPortugal | TAP Air Portugal | 10 | 4,157 mi6,690 km | 0m |
| UVF Vieux FortSaint Lucia | American Airlines | 10 | 1,505 mi2,422 km | 3h 30m |
| TYS Knoxville/MaryvilleUnited States | American Airlines, Envoy Air | 9 | 724 mi1,165 km | 2h 14m |
| MID MéridaMexico | American Airlines, Viva | 9 | 682 mi1,098 km | 1h 43m |
| HOU HoustonUnited States | Southwest Airlines | 9 | 955 mi1,537 km | 2h 41m |
| IAD DullesUnited States | United Airlines, American Airlines | 9 | 922 mi1,484 km | 2h 38m |
| SDF LouisvilleUnited States | American Airlines, Republic Airline | 8 | 910 mi1,465 km | 2h 36m |
| DAL DallasUnited States | Southwest Airlines | 8 | 1,109 mi1,785 km | 3h 3m |
| ILM WilmingtonUnited States | Envoy Air | 8 | 601 mi967 km | 1h 55m |
| OCJ BoscobelJamaica | Envoy Air | 8 | 551 mi887 km | 1h 45m |
| SRQ Sarasota/BradentonUnited States | Envoy Air | 8 | 178 mi286 km | 1h 4m |
| OKC Oklahoma CityUnited States | Envoy Air, Republic Airline | 8 | 1,222 mi1,967 km | 3h 20m |
| DOM MarigotDominica | Envoy Air | 8 | 1,415 mi2,277 km | 3h 22m |
| RTB Coxen HoleHonduras | American Airlines | 8 | 766 mi1,233 km | 2h 15m |
| TUL TulsaUnited States | Envoy Air | 7 | 1,168 mi1,880 km | 3h 10m |
| SAT San AntonioUnited States | American Airlines | 7 | 1,143 mi1,839 km | 3h 8m |
| XNA Fayetteville/Springdale/RogersUnited States | Envoy Air | 7 | 1,099 mi1,769 km | 3h 9m |
| ZRH ZurichSwitzerland | Swiss International Air Lines | 7 | 4,884 mi7,860 km | 0m |
| MDW ChicagoUnited States | Southwest Airlines | 7 | 1,182 mi1,902 km | 3h 11m |
| GIG Rio De JaneiroBrazil | American Airlines | 7 | 4,162 mi6,698 km | 8h 17m |
| BDL HartfordUnited States | American Airlines | 7 | 1,194 mi1,922 km | 3h 5m |
| FCO RomeItaly | American Airlines | 7 | 5,186 mi8,346 km | 4h 9m |
| SKB BasseterreSaint Kitts and Nevis | American Airlines | 7 | 1,271 mi2,045 km | 3h 6m |
| FRA Frankfurt am MainGermany | Lufthansa | 7 | 4,832 mi7,776 km | 0m |
| GNV GainesvilleUnited States | Envoy Air | 7 | 294 mi473 km | 1h 17m |
| GND Saint George'sGrenada | American Airlines | 7 | 1,535 mi2,470 km | 3h 39m |
| GEO GeorgetownGuyana | American Airlines | 7 | 1,969 mi3,169 km | 4h 11m |
| SNU Santa ClaraCuba | American Airlines | 7 | 228 mi367 km | 1h 8m |
| HOG HolguinCuba | American Airlines | 7 | 427 mi687 km | 1h 30m |
| CMW CamagueyCuba | American Airlines | 7 | 339 mi546 km | 1h 18m |
| CZM CozumelMexico | Envoy Air | 7 | 557 mi896 km | 1h 53m |
| BDA HamiltonBermuda | American Airlines | 7 | 1,046 mi1,683 km | 2h 37m |
| VPS ValparaisoUnited States | Envoy Air | 7 | 499 mi803 km | 1h 48m |
| AVL AshevilleUnited States | Envoy Air | 7 | 677 mi1,090 km | 2h 8m |
| MXP Ferno (VA)Italy | American Airlines | 7 | 4,930 mi7,934 km | 9h 26m |
| MEM MemphisUnited States | American Airlines | 7 | 859 mi1,382 km | 2h 33m |
| VRA MatanzasCuba | American Airlines | 7 | 203 mi327 km | 59m |
| TLV Tel AvivIsrael | El Al | 7 | 6,603 mi10,626 km | 0m |
| TQO TulumMexico | American Airlines, Envoy Air | 6 | 609 mi980 km | 1h 58m |
| PTP Pointe-Ã -PitreGuadeloupe | Air France, American Airlines | 5 | 1,375 mi2,213 km | 1h 0m |
| SVD KingstownSaint Vincent and the Grenadines | American Airlines | 5 | 1,515 mi2,438 km | 3h 36m |
| LRM La RomanaDominican Republic | American Airlines | 5 | 887 mi1,427 km | 2h 23m |
| GDL GuadalajaraMexico | Volaris | 5 | 1,507 mi2,425 km | 0m |
| SCU SantiagoCuba | American Airlines | 5 | 491 mi790 km | 1h 36m |
| GHB Governor's HarbourBahamas | Envoy Air | 5 | 250 mi402 km | 1h 8m |
| BON KralendijkCaribbean Netherlands | American Airlines | 4 | 1,224 mi1,970 km | 3h 3m |
| WAW WarsawPoland | LOT Polish Airlines | 4 | 5,286 mi8,507 km | 0m |
| MAR MaracaiboVenezuela | Envoy Air | 4 | 1,188 mi1,912 km | 3h 9m |
| CMN CasablancaMorocco | Royal Air Maroc | 3 | 4,321 mi6,954 km | 0m |
| FOR FortalezaBrazil | Gol Linhas Aéreas, LATAM Airlines Brasil | 3 | 3,458 mi5,565 km | 0m |
| AMS AmsterdamNetherlands | KLM | 3 | 4,633 mi7,456 km | 0m |
| FDF Fort-de-FranceMartinique | American Airlines | 3 | 1,468 mi2,363 km | 3h 27m |
| BIM South BiminiBahamas | Envoy Air | 3 | 64 mi103 km | 45m |
| GRR Grand RapidsUnited States | American Airlines | 2 | 1,214 mi1,954 km | 3h 17m |
| YVR VancouverCanada | Air Canada Rouge | 2 | 2,801 mi4,508 km | 0m |
| XSC South CaicosTurks and Caicos Islands | Envoy Air | 2 | 628 mi1,011 km | 1h 56m |
| MAO ManausBrazil | Gol Linhas Aéreas | 2 | 2,402 mi3,866 km | 0m |
| BEL BelémBrazil | Gol Linhas Aéreas | 2 | 2,831 mi4,556 km | 0m |
| DSM Des MoinesUnited States | Republic Airline | <1 | 1,327 mi2,136 km | 3h 41m |
| LIT Little RockUnited States | Republic Airline | <1 | 941 mi1,514 km | 2h 47m |
| ICT WichitaUnited States | Envoy Air | <1 | 1,295 mi2,084 km | 3h 39m |
| SGF SpringfieldUnited States | Envoy Air | <1 | 1,102 mi1,773 km | 3h 9m |
| CHA ChattanoogaUnited States | Republic Airline | <1 | 701 mi1,128 km | 2h 17m |
| HSV HuntsvilleUnited States | Envoy Air | <1 | 722 mi1,162 km | 2h 20m |
| JAN JacksonUnited States | Republic Airline | <1 | 742 mi1,194 km | 2h 21m |
| CAE ColumbiaUnited States | Republic Airline | <1 | 563 mi906 km | 1h 56m |