| ATL AtlantaUnited States | Delta Air Lines, Frontier Airlines, American Airlines, PSA Airlines | 119 | 666 mi1,072 km | 2h 12m |
| ORD ChicagoUnited States | American Airlines, United Airlines, Frontier Airlines | 102 | 678 mi1,091 km | 2h 28m |
| BOS BostonUnited States | American Airlines, Republic Airline, JetBlue | 92 | 280 mi451 km | 1h 23m |
| MCO OrlandoUnited States | American Airlines, Frontier Airlines, Southwest Airlines | 91 | 862 mi1,387 km | 2h 38m |
| DEN DenverUnited States | American Airlines, United Airlines, Southwest Airlines, Frontier Airlines | 74 | 1,558 mi2,507 km | 4h 9m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Frontier Airlines | 73 | 1,303 mi2,097 km | 3h 41m |
| FLL Fort LauderdaleUnited States | American Airlines, JetBlue, Frontier Airlines | 70 | 993 mi1,598 km | 2h 49m |
| MIA MiamiUnited States | American Airlines, Frontier Airlines | 67 | 1,013 mi1,630 km | 2h 51m |
| CLT CharlotteUnited States | American Airlines, Frontier Airlines | 63 | 449 mi723 km | 1h 46m |
| DTW DetroitUnited States | Delta Air Lines, PSA Airlines, Frontier Airlines, Piedmont Airlines | 61 | 453 mi729 km | 1h 44m |
| BNA NashvilleUnited States | American Airlines, Southwest Airlines, PSA Airlines | 56 | 675 mi1,086 km | 2h 12m |
| RDU Raleigh/DurhamUnited States | American Airlines, Frontier Airlines, PSA Airlines, Republic Airline | 56 | 337 mi542 km | 1h 29m |
| LAX Los AngelesUnited States | American Airlines | 55 | 2,402 mi3,866 km | 5h 47m |
| YYZ TorontoCanada | Piedmont Airlines, Jazz Aviation, PSA Airlines, Republic Airline | 52 | 347 mi558 km | 1h 9m |
| SFO San FranciscoUnited States | American Airlines, United Airlines | 52 | 2,522 mi4,059 km | 6h 10m |
| TPA TampaUnited States | American Airlines, Frontier Airlines | 48 | 920 mi1,481 km | 2h 42m |
| PHX PhoenixUnited States | American Airlines | 47 | 2,076 mi3,341 km | 5h 8m |
| MSP MinneapolisUnited States | Delta Air Lines, PSA Airlines, Sun Country Airlines, American Airlines | 47 | 981 mi1,579 km | 2h 53m |
| SEA SeattleUnited States | American Airlines, Alaska Airlines, Delta Air Lines | 40 | 2,379 mi3,829 km | 6h 5m |
| SJU San JuanPuerto Rico | Frontier Airlines, American Airlines, JetBlue | 40 | 1,576 mi2,536 km | 3h 53m |
| IAH HoustonUnited States | American Airlines, United Airlines, Mesa Airlines | 39 | 1,325 mi2,132 km | 3h 36m |
| ORF NorfolkUnited States | Piedmont Airlines, PSA Airlines, Republic Airline | 39 | 212 mi341 km | 1h 11m |
| CMH ColumbusUnited States | American Airlines, PSA Airlines, Republic Airline | 38 | 407 mi655 km | 1h 40m |
| IND IndianapolisUnited States | PSA Airlines, American Airlines, Republic Airline | 36 | 588 mi946 km | 2h 3m |
| JAX JacksonvilleUnited States | American Airlines, Frontier Airlines, PSA Airlines | 33 | 742 mi1,194 km | 2h 17m |
| LAS Las VegasUnited States | American Airlines, Frontier Airlines | 33 | 2,177 mi3,504 km | 5h 22m |
| PIT PittsburghUnited States | American Airlines, PSA Airlines, Piedmont Airlines | 32 | 268 mi431 km | 1h 18m |
| STL St LouisUnited States | American Airlines, Southwest Airlines, PSA Airlines | 32 | 814 mi1,310 km | 2h 26m |
| MDT HarrisburgUnited States | Piedmont Airlines | 32 | 84 mi135 km | 55m |
| RIC RichmondUnited States | Piedmont Airlines | 32 | 198 mi319 km | 1h 13m |
| MDW ChicagoUnited States | Southwest Airlines | 32 | 668 mi1,075 km | 2h 5m |
| ALB AlbanyUnited States | Piedmont Airlines | 32 | 212 mi341 km | 1h 18m |
| YUL MontréalCanada | Piedmont Airlines, Jazz Aviation | 31 | 394 mi634 km | 1h 11m |
| CLE ClevelandUnited States | Piedmont Airlines, PSA Airlines, American Airlines | 31 | 363 mi584 km | 1h 37m |
| CVG Cincinnati / CovingtonUnited States | PSA Airlines | 30 | 507 mi816 km | 1h 59m |
| SYR SyracuseUnited States | Piedmont Airlines | 29 | 228 mi367 km | 1h 18m |
| ILM WilmingtonUnited States | Piedmont Airlines | 26 | 414 mi666 km | 1h 37m |
| GSP Greenville/Greer/SpartanburgUnited States | Piedmont Airlines, PSA Airlines | 26 | 515 mi829 km | 1h 57m |
| MHT ManchesterUnited States | Piedmont Airlines | 26 | 289 mi465 km | 1h 25m |
| PWM PortlandUnited States | American Airlines, Piedmont Airlines | 25 | 364 mi586 km | 1h 28m |
| BUF BuffaloUnited States | Piedmont Airlines | 25 | 279 mi449 km | 1h 27m |
| IAD DullesUnited States | Republic Airline, Mesa Airlines, GoJet Airlines | 25 | 135 mi217 km | 1h 6m |
| BDL HartfordUnited States | Piedmont Airlines | 25 | 195 mi314 km | 1h 10m |
| ROC RochesterUnited States | Piedmont Airlines | 25 | 257 mi414 km | 1h 25m |
| BTV BurlingtonUnited States | PSA Airlines, American Airlines | 24 | 335 mi539 km | 1h 26m |
| PVD Providence/WarwickUnited States | PSA Airlines, American Airlines | 23 | 237 mi381 km | 1h 13m |
| MYR Myrtle BeachUnited States | Piedmont Airlines, Frontier Airlines | 23 | 474 mi763 km | 1h 47m |
| TYS Knoxville/MaryvilleUnited States | Piedmont Airlines, PSA Airlines, Allegiant Air | 22 | 555 mi893 km | 2h 4m |
| MSY New OrleansUnited States | American Airlines, PSA Airlines, Frontier Airlines | 22 | 1,089 mi1,753 km | 3h 3m |
| CUN CancúnMexico | American Airlines, Frontier Airlines | 21 | 1,468 mi2,363 km | 3h 56m |
| PUJ Punta CanaDominican Republic | American Airlines, Frontier Airlines | 21 | 1,524 mi2,453 km | 3h 53m |
| SAV SavannahUnited States | PSA Airlines, American Airlines, Piedmont Airlines | 21 | 630 mi1,014 km | 2h 6m |
| RSW Fort MyersUnited States | American Airlines | 21 | 993 mi1,598 km | 2h 54m |
| LHR LondonUnited Kingdom | American Airlines, British Airways | 21 | 3,545 mi5,705 km | 4h 17m |
| SAN San DiegoUnited States | American Airlines | 20 | 2,370 mi3,814 km | 5h 45m |
| PDX PortlandUnited States | American Airlines, Alaska Airlines | 20 | 2,406 mi3,872 km | 5h 47m |
| BGR BangorUnited States | Piedmont Airlines, American Airlines | 20 | 473 mi761 km | 1h 43m |
| AUS AustinUnited States | American Airlines | 20 | 1,431 mi2,303 km | 3h 50m |
| SCE State CollegeUnited States | Piedmont Airlines | 19 | 153 mi246 km | 1h 6m |
| MCI Kansas CityUnited States | American Airlines | 19 | 1,038 mi1,670 km | 3h 2m |
| AVL AshevilleUnited States | Piedmont Airlines, PSA Airlines | 19 | 504 mi811 km | 2h 0m |
| SDF LouisvilleUnited States | Republic Airline, PSA Airlines, Piedmont Airlines | 19 | 577 mi929 km | 2h 12m |
| MEM MemphisUnited States | PSA Airlines | 19 | 875 mi1,408 km | 2h 41m |
| CHS CharlestonUnited States | American Airlines, PSA Airlines | 18 | 550 mi885 km | 1h 55m |
| GRR Grand RapidsUnited States | PSA Airlines, Allegiant Air | 18 | 573 mi922 km | 2h 2m |
| MKE MilwaukeeUnited States | PSA Airlines, American Airlines | 18 | 690 mi1,110 km | 2h 20m |
| MSN MadisonUnited States | PSA Airlines | 17 | 764 mi1,230 km | 2h 28m |
| SLC Salt Lake CityUnited States | Delta Air Lines, American Airlines | 17 | 1,927 mi3,101 km | 4h 57m |
| DSM Des MoinesUnited States | PSA Airlines, Allegiant Air, Republic Airline | 14 | 973 mi1,566 km | 2h 53m |
| DCA WashingtonUnited States | PSA Airlines, Republic Airline | 14 | 120 mi193 km | 1h 18m |
| DUB DublinIreland | Aer Lingus, American Airlines | 14 | 3,272 mi5,266 km | 3h 31m |
| SDQ Santo DomingoDominican Republic | American Airlines, Frontier Airlines | 14 | 1,514 mi2,437 km | 3h 50m |
| CAE ColumbiaUnited States | Piedmont Airlines | 14 | 523 mi842 km | 1h 55m |
| ACK NantucketUnited States | Republic Airline | 13 | 288 mi463 km | 1h 28m |
| GSO GreensboroUnited States | Piedmont Airlines, PSA Airlines | 13 | 365 mi587 km | 1h 33m |
| SAT San AntonioUnited States | American Airlines | 13 | 1,496 mi2,408 km | 3h 52m |
| XNA Fayetteville/Springdale/RogersUnited States | American Airlines, PSA Airlines | 13 | 1,067 mi1,717 km | 3h 9m |
| OMA OmahaUnited States | PSA Airlines | 13 | 1,089 mi1,753 km | 3h 7m |
| YQB QuebecCanada | Piedmont Airlines, PSA Airlines | 13 | 515 mi829 km | 1h 58m |
| LEX LexingtonUnited States | PSA Airlines | 13 | 520 mi837 km | 1h 50m |
| ROA RoanokeUnited States | Piedmont Airlines | 12 | 311 mi501 km | 1h 32m |
| BHM BirminghamUnited States | PSA Airlines | 12 | 772 mi1,242 km | 2h 25m |
| ART WatertownUnited States | Piedmont Airlines | 9 | 287 mi462 km | 1h 24m |
| AUA OranjestadAruba | American Airlines | 8 | 1,911 mi3,075 km | 4h 29m |
| NAS NassauBahamas | American Airlines | 8 | 1,031 mi1,659 km | 2h 58m |
| MBJ Montego BayJamaica | American Airlines | 8 | 1,481 mi2,383 km | 3h 44m |
| SRQ Sarasota/BradentonUnited States | American Airlines, PSA Airlines | 7 | 957 mi1,540 km | 2h 51m |
| TVC Traverse CityUnited States | PSA Airlines | 7 | 627 mi1,009 km | 2h 14m |
| FCO RomeItaly | American Airlines | 7 | 4,371 mi7,034 km | 8h 9m |
| MAD MadridSpain | American Airlines | 7 | 3,681 mi5,924 km | 6h 54m |
| CDG Paris (Roissy-en-France, Val-d'Oise)France | American Airlines | 7 | 3,729 mi6,001 km | 7h 11m |
| BCN BarcelonaSpain | American Airlines | 7 | 3,925 mi6,317 km | 7h 25m |
| AMS AmsterdamNetherlands | American Airlines | 7 | 3,736 mi6,013 km | 7h 15m |
| ATH Spata-ArtemidaGreece | American Airlines | 7 | 5,034 mi8,101 km | 9h 19m |
| VCE Venezia (VE)Italy | American Airlines | 7 | 4,248 mi6,836 km | 8h 2m |
| MXP Ferno (VA)Italy | American Airlines | 7 | 4,089 mi6,581 km | 7h 49m |
| NAP NapoliItaly | American Airlines | 7 | 4,495 mi7,234 km | 8h 34m |
| YHZ HalifaxCanada | American Airlines | 7 | 692 mi1,114 km | 2h 1m |
| CPH CopenhagenDenmark | American Airlines | 7 | 3,947 mi6,352 km | 7h 28m |
| MVY Martha's VineyardUnited States | Republic Airline | 7 | 265 mi426 km | 1h 25m |
| BUD BudapestHungary | American Airlines | 7 | 4,464 mi7,184 km | 8h 21m |
| PRG PragueCzech Republic | American Airlines | 7 | 4,174 mi6,717 km | 7h 55m |
| EYW Key WestUnited States | American Airlines | 7 | 1,122 mi1,806 km | 3h 14m |
| LIS LisbonPortugal | American Airlines | 7 | 3,457 mi5,564 km | 6h 37m |
| PNS PensacolaUnited States | PSA Airlines | 7 | 935 mi1,505 km | 2h 46m |
| EDI Ingliston, EdinburghUnited Kingdom | American Airlines | 7 | 3,348 mi5,388 km | 6h 39m |
| NCE Nice, Alpes-MaritimesFrance | American Airlines | 7 | 4,085 mi6,574 km | 7h 45m |
| ECP Panama City BeachUnited States | PSA Airlines | 7 | 886 mi1,426 km | 2h 39m |
| STI SantiagoDominican Republic | American Airlines, Frontier Airlines | 7 | 1,437 mi2,313 km | 3h 44m |
| HYA HyannisUnited States | Republic Airline | 7 | 288 mi463 km | 1h 24m |
| ZRH ZurichSwitzerland | American Airlines | 7 | 4,025 mi6,478 km | 7h 32m |
| DAL DallasUnited States | Southwest Airlines | 7 | 1,295 mi2,084 km | 3h 22m |
| SBY SalisburyUnited States | Piedmont Airlines | 6 | 107 mi172 km | 57m |
| ORH WorcesterUnited States | Piedmont Airlines | 6 | 241 mi388 km | 1h 14m |
| FRA Frankfurt am MainGermany | Discover Airlines | 6 | 3,948 mi6,354 km | 0m |
| DAY DaytonUnited States | PSA Airlines | 6 | 477 mi768 km | 1h 48m |
| JFK New YorkUnited States | American Airlines, Delta Air Lines, Republic Airline | 5 | 93 mi150 km | 1h 15m |
| EWR NewarkUnited States | United Airlines, Republic Airline | 5 | 80 mi129 km | 1h 9m |
| PLS ProvidencialesTurks and Caicos Islands | American Airlines | 5 | 1,259 mi2,026 km | 3h 31m |
| BDA HamiltonBermuda | American Airlines | 5 | 784 mi1,262 km | 2h 14m |
| LGA New YorkUnited States | American Airlines, Republic Airline | 5 | 95 mi153 km | 1h 7m |
| SXM Sint MaartenSint Maarten | American Airlines | 4 | 1,670 mi2,688 km | 4h 10m |
| STT Charlotte AmalieU.S. Virgin Islands | American Airlines | <1 | 1,605 mi2,583 km | 3h 58m |
| HHH Hilton Head IslandUnited States | Republic Airline | <1 | 609 mi980 km | 2h 14m |
| GCM George TownCayman Islands | American Airlines | <1 | 1,464 mi2,356 km | 3h 50m |
| UVF Vieux FortSaint Lucia | American Airlines | <1 | 1,998 mi3,215 km | 4h 35m |
| VPS ValparaisoUnited States | PSA Airlines | <1 | 908 mi1,461 km | 2h 55m |