| ATL AtlantaUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 107 | 577 mi929 km | 1h 54m |
| MCO OrlandoUnited States | Southwest Airlines, Frontier Airlines | 82 | 787 mi1,267 km | 2h 20m |
| BOS BostonUnited States | Southwest Airlines, Republic Airline | 69 | 369 mi594 km | 1h 26m |
| FLL Fort LauderdaleUnited States | Southwest Airlines, JetBlue, Frontier Airlines | 60 | 925 mi1,489 km | 2h 33m |
| CLT CharlotteUnited States | American Airlines, Southwest Airlines, Frontier Airlines, PSA Airlines | 59 | 361 mi581 km | 1h 29m |
| DEN DenverUnited States | Southwest Airlines, United Airlines | 57 | 1,491 mi2,400 km | 3h 55m |
| ORD ChicagoUnited States | United Airlines, Republic Airline, Envoy Air | 52 | 622 mi1,001 km | 2h 18m |
| TPA TampaUnited States | Southwest Airlines, Frontier Airlines | 47 | 842 mi1,355 km | 2h 24m |
| DTW DetroitUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 46 | 409 mi658 km | 1h 29m |
| MIA MiamiUnited States | Southwest Airlines, American Airlines, Frontier Airlines | 41 | 946 mi1,522 km | 2h 38m |
| MDW ChicagoUnited States | Southwest Airlines | 39 | 611 mi983 km | 1h 56m |
| MSP MinneapolisUnited States | Delta Air Lines, Southwest Airlines, Sun Country Airlines | 37 | 936 mi1,506 km | 2h 39m |
| DAL DallasUnited States | Southwest Airlines | 37 | 1,209 mi1,946 km | 3h 10m |
| RDU Raleigh/DurhamUnited States | Southwest Airlines | 34 | 256 mi412 km | 1h 6m |
| LAS Las VegasUnited States | Southwest Airlines | 33 | 2,106 mi3,389 km | 5h 4m |
| BNA NashvilleUnited States | Southwest Airlines | 33 | 587 mi945 km | 1h 52m |
| MHT ManchesterUnited States | Southwest Airlines | 33 | 377 mi607 km | 1h 18m |
| BUF BuffaloUnited States | Southwest Airlines | 33 | 281 mi452 km | 1h 8m |
| LAX Los AngelesUnited States | Southwest Airlines, United Airlines | 33 | 2,329 mi3,748 km | 5h 35m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Frontier Airlines | 33 | 1,217 mi1,959 km | 3h 26m |
| PVD Providence/WarwickUnited States | Southwest Airlines | 32 | 327 mi526 km | 1h 12m |
| ALB AlbanyUnited States | Southwest Airlines | 32 | 288 mi463 km | 1h 10m |
| HOU HoustonUnited States | Southwest Airlines | 32 | 1,246 mi2,005 km | 3h 16m |
| ISP IslipUnited States | Southwest Airlines | 32 | 220 mi354 km | 1h 3m |
| BDL HartfordUnited States | Southwest Airlines | 31 | 283 mi455 km | 1h 8m |
| ORF NorfolkUnited States | Southwest Airlines | 31 | 159 mi256 km | 51m |
| STL St LouisUnited States | Southwest Airlines | 28 | 738 mi1,188 km | 2h 11m |
| PWM PortlandUnited States | Southwest Airlines | 27 | 452 mi727 km | 1h 23m |
| SJU San JuanPuerto Rico | Southwest Airlines, Frontier Airlines | 27 | 1,565 mi2,519 km | 3h 57m |
| IND IndianapolisUnited States | Southwest Airlines | 26 | 516 mi830 km | 1h 43m |
| JAX JacksonvilleUnited States | Southwest Airlines | 25 | 663 mi1,067 km | 2h 0m |
| CHS CharlestonUnited States | Southwest Airlines | 23 | 472 mi760 km | 1h 38m |
| SAN San DiegoUnited States | Southwest Airlines | 23 | 2,295 mi3,693 km | 5h 27m |
| AUS AustinUnited States | Southwest Airlines | 23 | 1,342 mi2,160 km | 3h 30m |
| IAH HoustonUnited States | United Airlines, Frontier Airlines | 23 | 1,235 mi1,988 km | 3h 20m |
| MYR Myrtle BeachUnited States | Southwest Airlines | 21 | 399 mi642 km | 1h 23m |
| SEA SeattleUnited States | Alaska Airlines, Southwest Airlines | 20 | 2,335 mi3,758 km | 5h 48m |
| CMH ColumbusUnited States | Southwest Airlines | 20 | 337 mi542 km | 1h 17m |
| SRQ Sarasota/BradentonUnited States | Southwest Airlines | 20 | 880 mi1,416 km | 2h 29m |
| ROC RochesterUnited States | Southwest Airlines | 20 | 277 mi446 km | 1h 10m |
| RSW Fort MyersUnited States | Southwest Airlines | 20 | 919 mi1,479 km | 2h 35m |
| MCI Kansas CityUnited States | Southwest Airlines | 20 | 966 mi1,555 km | 2h 41m |
| MSY New OrleansUnited States | Southwest Airlines | 19 | 998 mi1,606 km | 2h 42m |
| PIT PittsburghUnited States | Southwest Airlines | 19 | 210 mi338 km | 58m |
| CLE ClevelandUnited States | Southwest Airlines | 19 | 314 mi505 km | 1h 13m |
| MKE MilwaukeeUnited States | Southwest Airlines | 19 | 641 mi1,032 km | 1h 58m |
| SFO San FranciscoUnited States | United Airlines, Southwest Airlines | 19 | 2,457 mi3,954 km | 5h 55m |
| SAV SavannahUnited States | Southwest Airlines | 18 | 548 mi882 km | 1h 46m |
| SDF LouisvilleUnited States | Southwest Airlines | 18 | 495 mi797 km | 1h 41m |
| SAT San AntonioUnited States | Southwest Airlines | 17 | 1,407 mi2,264 km | 3h 34m |
| CUN CancúnMexico | Southwest Airlines | 16 | 1,388 mi2,234 km | 3h 40m |
| PUJ Punta CanaDominican Republic | Southwest Airlines | 16 | 1,504 mi2,420 km | 3h 51m |
| SLC Salt Lake CityUnited States | Southwest Airlines, Delta Air Lines | 14 | 1,865 mi3,001 km | 4h 43m |
| PHX PhoenixUnited States | Southwest Airlines | 14 | 1,999 mi3,217 km | 4h 55m |
| PDX PortlandUnited States | Alaska Airlines, Southwest Airlines | 14 | 2,358 mi3,795 km | 5h 29m |
| GSP Greenville/Greer/SpartanburgUnited States | Southwest Airlines | 14 | 426 mi686 km | 1h 28m |
| RIC RichmondUnited States | Southwest Airlines | 13 | 120 mi193 km | 47m |
| CVG Cincinnati / CovingtonUnited States | Southwest Airlines | 13 | 430 mi692 km | 1h 31m |
| GRR Grand RapidsUnited States | Southwest Airlines | 13 | 528 mi850 km | 1h 39m |
| MBJ Montego BayJamaica | Southwest Airlines | 12 | 1,426 mi2,295 km | 3h 23m |
| KEF ReykjavÃkIceland | Icelandair | 10 | 2,762 mi4,445 km | 0m |
| MCN MaconUnited States | Contour Airlines | 9 | 594 mi956 km | 2h 13m |
| ABQ AlbuquerqueUnited States | Southwest Airlines | 7 | 1,670 mi2,688 km | 4h 9m |
| SMF SacramentoUnited States | Southwest Airlines | 7 | 2,395 mi3,854 km | 5h 41m |
| ONT OntarioUnited States | Southwest Airlines | 7 | 2,283 mi3,674 km | 5h 20m |
| SJC San JoseUnited States | Southwest Airlines | 7 | 2,439 mi3,925 km | 5h 40m |
| VPS ValparaisoUnited States | Southwest Airlines | 7 | 819 mi1,318 km | 2h 17m |
| BHM BirminghamUnited States | Southwest Airlines | 7 | 682 mi1,098 km | 1h 58m |
| LHR LondonUnited Kingdom | British Airways | 6 | 3,634 mi5,848 km | 0m |
| TYS Knoxville/MaryvilleUnited States | Southwest Airlines | 6 | 464 mi747 km | 1h 31m |
| MEM MemphisUnited States | Southwest Airlines | 6 | 787 mi1,267 km | 2h 13m |
| PTY TocumenPanama | Copa Airlines | 5 | 2,079 mi3,346 km | 0m |
| AUA OranjestadAruba | Southwest Airlines | 5 | 1,881 mi3,027 km | 4h 23m |
| HVN New HavenUnited States | Avelo Airlines | 4 | 246 mi396 km | 1h 26m |
| LGA New YorkUnited States | Delta Air Lines, Southwest Airlines | 2 | 185 mi298 km | 1h 16m |
| BDA HamiltonBermuda | BermudAir | 2 | 820 mi1,320 km | 0m |
| ILM WilmingtonUnited States | Avelo Airlines | 2 | 345 mi555 km | 1h 20m |
| STT Charlotte AmalieU.S. Virgin Islands | Southwest Airlines | 2 | 1,598 mi2,572 km | 4h 7m |
| NAS NassauBahamas | Southwest Airlines | 2 | 975 mi1,569 km | 2h 36m |
| LIR LiberiaCosta Rica | Southwest Airlines | 2 | 2,042 mi3,286 km | 4h 46m |
| SJO San José (Alajuela)Costa Rica | Southwest Airlines | 2 | 2,062 mi3,318 km | 4h 43m |
| SXM Sint MaartenSint Maarten | Southwest Airlines | 2 | 1,668 mi2,684 km | 4h 24m |
| ECP Panama City BeachUnited States | Southwest Airlines | 1 | 798 mi1,284 km | 2h 14m |
| DCA WashingtonUnited States | Southwest Airlines | 1 | 30 mi48 km | 43m |
| PLS ProvidencialesTurks and Caicos Islands | Southwest Airlines | <1 | 1,227 mi1,975 km | 3h 21m |
| GCM George TownCayman Islands | Southwest Airlines | <1 | 1,398 mi2,250 km | 3h 23m |
| BZE Belize CityBelize | Southwest Airlines | <1 | 1,646 mi2,649 km | 3h 53m |
| EWR NewarkUnited States | United Airlines | <1 | 169 mi272 km | 1h 34m |