| ORD ChicagoUnited States | SkyWest Airlines, Envoy Air, Delta Air Lines, United Airlines, Republic Airline, Endeavor Air, American Airlines | 121 | 235 mi378 km | 1h 32m |
| ATL AtlantaUnited States | Delta Air Lines, Frontier Airlines | 94 | 594 mi956 km | 1h 57m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Delta Air Lines, Frontier Airlines | 70 | 986 mi1,587 km | 2h 55m |
| DEN DenverUnited States | Delta Air Lines, Frontier Airlines, Southwest Airlines, United Airlines | 66 | 1,123 mi1,807 km | 3h 9m |
| CLT CharlotteUnited States | American Airlines, Delta Air Lines | 63 | 500 mi805 km | 1h 47m |
| PHL PhiladelphiaUnited States | Delta Air Lines, PSA Airlines, Frontier Airlines, Piedmont Airlines | 62 | 453 mi729 km | 1h 36m |
| MCO OrlandoUnited States | Delta Air Lines, Frontier Airlines | 60 | 957 mi1,540 km | 2h 38m |
| EWR NewarkUnited States | Delta Air Lines, Republic Airline, United Airlines | 60 | 488 mi785 km | 1h 42m |
| LGA New YorkUnited States | Delta Air Lines, Republic Airline | 54 | 502 mi808 km | 1h 44m |
| YYZ TorontoCanada | Endeavor Air, Jazz Aviation | 53 | 214 mi344 km | 59m |
| IAH HoustonUnited States | Delta Air Lines, Mesa Airlines, Frontier Airlines, United Airlines | 52 | 1,075 mi1,730 km | 3h 2m |
| BOS BostonUnited States | Delta Air Lines, JetBlue | 51 | 632 mi1,017 km | 1h 53m |
| DCA WashingtonUnited States | Delta Air Lines, PSA Airlines, Republic Airline | 49 | 405 mi652 km | 1h 39m |
| SEA SeattleUnited States | Delta Air Lines, Alaska Airlines | 48 | 1,927 mi3,101 km | 4h 57m |
| PHX PhoenixUnited States | Delta Air Lines, American Airlines, Frontier Airlines | 47 | 1,671 mi2,689 km | 4h 15m |
| BNA NashvilleUnited States | Delta Air Lines, Southwest Airlines | 47 | 456 mi734 km | 1h 37m |
| IND IndianapolisUnited States | Endeavor Air, Republic Airline, SkyWest Airlines | 47 | 231 mi372 km | 1h 12m |
| GRR Grand RapidsUnited States | Endeavor Air, SkyWest Airlines, Republic Airline | 46 | 120 mi193 km | 55m |
| BWI BaltimoreUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 45 | 409 mi658 km | 1h 26m |
| IAD DullesUnited States | Mesa Airlines, Delta Air Lines, SkyWest Airlines, Republic Airline | 45 | 383 mi616 km | 1h 31m |
| MSP MinneapolisUnited States | Delta Air Lines, Sun Country Airlines | 45 | 528 mi850 km | 1h 52m |
| LAS Las VegasUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 44 | 1,749 mi2,815 km | 4h 21m |
| SFO San FranciscoUnited States | Delta Air Lines, United Airlines | 42 | 2,079 mi3,346 km | 5h 8m |
| FLL Fort LauderdaleUnited States | Delta Air Lines, JetBlue, Frontier Airlines | 42 | 1,127 mi1,814 km | 3h 2m |
| LAX Los AngelesUnited States | Delta Air Lines | 41 | 1,979 mi3,185 km | 4h 52m |
| CLE ClevelandUnited States | SkyWest Airlines, Endeavor Air | 41 | 95 mi153 km | 54m |
| MDW ChicagoUnited States | Endeavor Air, Southwest Airlines | 41 | 228 mi367 km | 1h 14m |
| CVG Cincinnati / CovingtonUnited States | Endeavor Air | 40 | 229 mi369 km | 1h 11m |
| CMH ColumbusUnited States | Republic Airline, SkyWest Airlines | 40 | 155 mi249 km | 1h 2m |
| STL St LouisUnited States | Delta Air Lines, Southwest Airlines | 39 | 440 mi708 km | 1h 36m |
| JFK New YorkUnited States | Delta Air Lines, Endeavor Air, JetBlue | 36 | 509 mi819 km | 1h 49m |
| MKE MilwaukeeUnited States | SkyWest Airlines, Delta Air Lines, Endeavor Air | 34 | 237 mi381 km | 1h 14m |
| SLC Salt Lake CityUnited States | Delta Air Lines | 34 | 1,481 mi2,383 km | 3h 55m |
| BUF BuffaloUnited States | SkyWest Airlines, Delta Air Lines | 34 | 241 mi388 km | 1h 10m |
| PIT PittsburghUnited States | Republic Airline, Endeavor Air, SkyWest Airlines | 33 | 201 mi323 km | 1h 8m |
| TPA TampaUnited States | Delta Air Lines, Frontier Airlines | 31 | 983 mi1,582 km | 2h 36m |
| TVC Traverse CityUnited States | SkyWest Airlines, Delta Air Lines, Endeavor Air | 28 | 207 mi333 km | 1h 8m |
| ALB AlbanyUnited States | SkyWest Airlines, Endeavor Air, Delta Air Lines | 27 | 489 mi787 km | 1h 33m |
| OMA OmahaUnited States | SkyWest Airlines | 27 | 650 mi1,046 km | 2h 7m |
| SYR SyracuseUnited States | SkyWest Airlines, Delta Air Lines | 27 | 374 mi602 km | 1h 21m |
| MSN MadisonUnited States | SkyWest Airlines, Endeavor Air, Delta Air Lines | 27 | 311 mi501 km | 1h 19m |
| ROC RochesterUnited States | Endeavor Air, Delta Air Lines, SkyWest Airlines | 27 | 296 mi476 km | 1h 18m |
| TYS Knoxville/MaryvilleUnited States | Endeavor Air | 27 | 443 mi713 km | 1h 35m |
| SDF LouisvilleUnited States | Endeavor Air, SkyWest Airlines, Republic Airline | 26 | 306 mi492 km | 1h 21m |
| MBS FreelandUnited States | SkyWest Airlines | 26 | 98 mi158 km | 53m |
| ATW AppletonUnited States | SkyWest Airlines, Endeavor Air | 26 | 296 mi476 km | 1h 20m |
| MCI Kansas CityUnited States | Delta Air Lines | 26 | 629 mi1,012 km | 1h 58m |
| YUL MontréalCanada | Endeavor Air, Jazz Aviation | 26 | 530 mi853 km | 1h 35m |
| AUS AustinUnited States | Delta Air Lines | 26 | 1,149 mi1,849 km | 3h 11m |
| AZO KalamazooUnited States | SkyWest Airlines | 26 | 113 mi182 km | 52m |
| BDL HartfordUnited States | Delta Air Lines | 25 | 549 mi884 km | 1h 37m |
| RDU Raleigh/DurhamUnited States | Delta Air Lines | 25 | 501 mi806 km | 1h 39m |
| SAN San DiegoUnited States | Delta Air Lines | 24 | 1,956 mi3,148 km | 4h 47m |
| MIA MiamiUnited States | Delta Air Lines, American Airlines, Envoy Air | 22 | 1,145 mi1,843 km | 3h 6m |
| ELM Elmira/CorningUnited States | SkyWest Airlines | 21 | 331 mi533 km | 1h 16m |
| LEX LexingtonUnited States | SkyWest Airlines, Endeavor Air, Republic Airline | 21 | 296 mi476 km | 1h 17m |
| LAN LansingUnited States | SkyWest Airlines, Endeavor Air | 21 | 74 mi119 km | 46m |
| ORF NorfolkUnited States | Delta Air Lines, Endeavor Air | 21 | 529 mi851 km | 1h 45m |
| GRB Green BayUnited States | SkyWest Airlines, Endeavor Air | 21 | 287 mi462 km | 1h 17m |
| RIC RichmondUnited States | Endeavor Air, Delta Air Lines, SkyWest Airlines | 21 | 455 mi732 km | 1h 38m |
| AMS AmsterdamNetherlands | Delta Air Lines | 21 | 3,940 mi6,341 km | 7h 40m |
| PVD Providence/WarwickUnited States | SkyWest Airlines | 21 | 615 mi990 km | 1h 50m |
| MDT HarrisburgUnited States | Endeavor Air, SkyWest Airlines | 21 | 371 mi597 km | 1h 24m |
| CDG Paris (Roissy-en-France, Val-d'Oise)France | Delta Air Lines, Air France | 21 | 3,963 mi6,378 km | 4h 37m |
| DSM Des MoinesUnited States | Endeavor Air | 21 | 534 mi859 km | 1h 52m |
| MEM MemphisUnited States | Delta Air Lines, SkyWest Airlines | 20 | 610 mi982 km | 1h 58m |
| BHM BirminghamUnited States | SkyWest Airlines, Delta Air Lines, Endeavor Air | 20 | 625 mi1,006 km | 1h 58m |
| BTV BurlingtonUnited States | Endeavor Air, SkyWest Airlines | 20 | 537 mi864 km | 1h 47m |
| GSP Greenville/Greer/SpartanburgUnited States | Endeavor Air, Delta Air Lines | 20 | 508 mi818 km | 1h 41m |
| GSO GreensboroUnited States | Endeavor Air | 20 | 460 mi740 km | 1h 39m |
| SAT San AntonioUnited States | Delta Air Lines | 19 | 1,214 mi1,954 km | 3h 11m |
| CHS CharlestonUnited States | Endeavor Air, Delta Air Lines | 19 | 667 mi1,073 km | 2h 8m |
| RSW Fort MyersUnited States | Delta Air Lines | 16 | 1,084 mi1,745 km | 2h 51m |
| SBN South BendUnited States | SkyWest Airlines | 14 | 157 mi253 km | 1h 0m |
| FWA Fort WayneUnited States | SkyWest Airlines, Endeavor Air | 14 | 128 mi206 km | 1h 0m |
| FRA Frankfurt am MainGermany | Delta Air Lines, Lufthansa | 14 | 4,161 mi6,696 km | 3h 43m |
| SAV SavannahUnited States | Delta Air Lines, SkyWest Airlines | 14 | 705 mi1,135 km | 2h 6m |
| CUN CancúnMexico | Delta Air Lines | 14 | 1,473 mi2,371 km | 3h 53m |
| PLN PellstonUnited States | SkyWest Airlines | 14 | 243 mi391 km | 1h 11m |
| PWM PortlandUnited States | Delta Air Lines | 14 | 668 mi1,075 km | 1h 50m |
| HPN White PlainsUnited States | Endeavor Air | 13 | 505 mi813 km | 1h 43m |
| CHA ChattanoogaUnited States | Endeavor Air | 13 | 505 mi813 km | 1h 41m |
| JAX JacksonvilleUnited States | Delta Air Lines | 13 | 813 mi1,308 km | 2h 15m |
| APN AlpenaUnited States | SkyWest Airlines | 12 | 198 mi319 km | 1h 7m |
| MSY New OrleansUnited States | Delta Air Lines | 12 | 926 mi1,490 km | 2h 33m |
| HSV HuntsvilleUnited States | Endeavor Air | 12 | 554 mi892 km | 1h 48m |
| PDX PortlandUnited States | Delta Air Lines | 10 | 1,953 mi3,143 km | 4h 46m |
| BGM BinghamtonUnited States | SkyWest Airlines | 7 | 378 mi608 km | 1h 19m |
| LHR LondonUnited Kingdom | Delta Air Lines | 7 | 3,766 mi6,061 km | 7h 30m |
| MEX Mexico CityMexico | Delta Air Lines | 7 | 1,819 mi2,927 km | 4h 34m |
| ICN SeoulSouth Korea | Delta Air Lines | 7 | 6,636 mi10,680 km | 14h 46m |
| XNA Fayetteville/Springdale/RogersUnited States | Endeavor Air | 7 | 715 mi1,151 km | 2h 23m |
| SJU San JuanPuerto Rico | Delta Air Lines | 7 | 1,930 mi3,106 km | 4h 26m |
| IMT KingsfordUnited States | SkyWest Airlines | 7 | 344 mi554 km | 1h 26m |
| IST IstanbulTurkey | Turkish Airlines | 7 | 5,297 mi8,525 km | 0m |
| FCO RomeItaly | Delta Air Lines | 7 | 4,627 mi7,446 km | 8h 55m |
| YYC CalgaryCanada | WestJet | 7 | 1,568 mi2,523 km | 0m |
| MUC MunichGermany | Delta Air Lines | 7 | 4,347 mi6,996 km | 8h 20m |
| YVR VancouverCanada | WestJet | 7 | 1,962 mi3,158 km | 0m |
| MYR Myrtle BeachUnited States | Delta Air Lines | 7 | 636 mi1,024 km | 1h 52m |
| HND TokyoJapan | Delta Air Lines | 7 | 6,428 mi10,345 km | 13h 29m |
| PVG Shanghai (Pudong)China | Delta Air Lines | 7 | 7,137 mi11,486 km | 15h 44m |
| CIU KincheloeUnited States | SkyWest Airlines | 7 | 285 mi459 km | 1h 15m |
| MQT GwinnUnited States | SkyWest Airlines | 7 | 349 mi562 km | 1h 28m |
| MTY MonterreyMexico | Aeroméxico Connect | 7 | 1,480 mi2,382 km | 0m |
| HNL Honolulu, OahuUnited States | Delta Air Lines | 7 | 4,475 mi7,202 km | 9h 43m |
| DUB DublinIreland | Delta Air Lines | 7 | 3,488 mi5,613 km | 7h 3m |
| ANC AnchorageUnited States | Delta Air Lines | 7 | 2,986 mi4,806 km | 6h 40m |
| ESC EscanabaUnited States | SkyWest Airlines | 7 | 306 mi492 km | 1h 17m |
| YHZ HalifaxCanada | WestJet | 6 | 1,011 mi1,627 km | 0m |
| SNA Santa AnaUnited States | Delta Air Lines | 6 | 1,960 mi3,154 km | 4h 54m |
| QRO QuerétaroMexico | Aeroméxico Connect | 6 | 1,782 mi2,868 km | 0m |
| KEF ReykjavÃkIceland | Delta Air Lines | 6 | 2,792 mi4,493 km | 2h 54m |
| AMM AmmanJordan | Royal Jordanian | 4 | 6,055 mi9,745 km | 0m |
| GDL GuadalajaraMexico | Volaris | 3 | 1,894 mi3,048 km | 0m |
| HVN New HavenUnited States | Avelo Airlines | 2 | 545 mi877 km | 1h 41m |
| BGR BangorUnited States | Delta Air Lines | 2 | 750 mi1,207 km | 2h 3m |
| PNS PensacolaUnited States | Delta Air Lines | 2 | 837 mi1,347 km | 2h 15m |
| BZN BozemanUnited States | Delta Air Lines | 2 | 1,400 mi2,253 km | 3h 38m |
| PUJ Punta CanaDominican Republic | Delta Air Lines | <1 | 1,852 mi2,981 km | 4h 18m |