| ORD ChicagoUnited States | GoJet Airlines, United Airlines, Envoy Air, SkyWest Airlines, American Airlines, Republic Airline | 111 | 258 mi415 km | 1h 30m |
| DEN DenverUnited States | Southwest Airlines, United Airlines, Frontier Airlines | 83 | 770 mi1,239 km | 2h 19m |
| ATL AtlantaUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 73 | 484 mi779 km | 1h 29m |
| LGA New YorkUnited States | Southwest Airlines, Endeavor Air, Republic Airline | 62 | 888 mi1,429 km | 2h 21m |
| MCO OrlandoUnited States | Southwest Airlines, Frontier Airlines | 52 | 882 mi1,419 km | 2h 16m |
| DFW Dallas-Fort WorthUnited States | American Airlines, PSA Airlines, Frontier Airlines | 49 | 550 mi885 km | 1h 55m |
| MSP MinneapolisUnited States | Delta Air Lines, Southwest Airlines, SkyWest Airlines, Endeavor Air | 48 | 448 mi721 km | 1h 33m |
| PHX PhoenixUnited States | Southwest Airlines, American Airlines | 44 | 1,262 mi2,031 km | 3h 17m |
| LAS Las VegasUnited States | Southwest Airlines, Frontier Airlines | 43 | 1,371 mi2,206 km | 3h 26m |
| DAL DallasUnited States | Southwest Airlines | 42 | 546 mi879 km | 1h 38m |
| DCA WashingtonUnited States | Southwest Airlines, American Airlines, PSA Airlines, Republic Airline | 42 | 719 mi1,157 km | 1h 58m |
| MDW ChicagoUnited States | Southwest Airlines | 40 | 251 mi404 km | 1h 2m |
| CLT CharlotteUnited States | American Airlines, Southwest Airlines, PSA Airlines | 40 | 575 mi925 km | 1h 45m |
| DTW DetroitUnited States | Delta Air Lines, Southwest Airlines | 40 | 440 mi708 km | 1h 26m |
| HOU HoustonUnited States | Southwest Airlines | 33 | 687 mi1,106 km | 1h 59m |
| PHL PhiladelphiaUnited States | American Airlines, Southwest Airlines, PSA Airlines | 32 | 814 mi1,310 km | 2h 6m |
| BOS BostonUnited States | Southwest Airlines, Republic Airline, Envoy Air | 32 | 1,047 mi1,685 km | 2h 30m |
| IAH HoustonUnited States | Mesa Airlines, GoJet Airlines, SkyWest Airlines, United Airlines | 30 | 667 mi1,073 km | 2h 10m |
| BNA NashvilleUnited States | Southwest Airlines | 28 | 272 mi438 km | 1h 3m |
| SEA SeattleUnited States | Alaska Airlines, Southwest Airlines | 28 | 1,709 mi2,750 km | 4h 24m |
| BWI BaltimoreUnited States | Southwest Airlines | 27 | 738 mi1,188 km | 1h 53m |
| TPA TampaUnited States | Southwest Airlines | 23 | 869 mi1,399 km | 2h 11m |
| MIA MiamiUnited States | Southwest Airlines, American Airlines, Envoy Air | 22 | 1,068 mi1,719 km | 2h 41m |
| CUN CancúnMexico | Southwest Airlines, Frontier Airlines | 22 | 1,237 mi1,991 km | 3h 10m |
| MCI Kansas CityUnited States | Southwest Airlines | 21 | 237 mi381 km | 1h 1m |
| LAX Los AngelesUnited States | Southwest Airlines, SkyWest Airlines | 21 | 1,592 mi2,562 km | 4h 3m |
| AUS AustinUnited States | Southwest Airlines | 20 | 721 mi1,160 km | 1h 59m |
| SLC Salt Lake CityUnited States | Delta Air Lines | 20 | 1,156 mi1,860 km | 3h 13m |
| EWR NewarkUnited States | Republic Airline, United Airlines | 18 | 872 mi1,403 km | 2h 26m |
| FLL Fort LauderdaleUnited States | Southwest Airlines | 16 | 1,057 mi1,701 km | 2h 33m |
| OMA OmahaUnited States | Southwest Airlines | 15 | 342 mi550 km | 1h 12m |
| RSW Fort MyersUnited States | Southwest Airlines | 15 | 979 mi1,576 km | 2h 21m |
| SFO San FranciscoUnited States | United Airlines, Southwest Airlines | 14 | 1,735 mi2,792 km | 4h 27m |
| IAD DullesUnited States | GoJet Airlines | 14 | 696 mi1,120 km | 2h 2m |
| RDU Raleigh/DurhamUnited States | Southwest Airlines | 14 | 668 mi1,075 km | 1h 43m |
| MSY New OrleansUnited States | Southwest Airlines | 14 | 604 mi972 km | 1h 39m |
| PIT PittsburghUnited States | Southwest Airlines | 14 | 554 mi892 km | 1h 31m |
| CMH ColumbusUnited States | Southwest Airlines | 13 | 409 mi658 km | 1h 16m |
| CLE ClevelandUnited States | Southwest Airlines | 13 | 487 mi784 km | 1h 25m |
| MKE MilwaukeeUnited States | Southwest Airlines | 13 | 317 mi510 km | 1h 8m |
| YYZ TorontoCanada | Jazz Aviation | 13 | 654 mi1,053 km | 0m |
| SAT San AntonioUnited States | Southwest Airlines | 12 | 786 mi1,265 km | 2h 6m |
| ECP Panama City BeachUnited States | Southwest Airlines | 10 | 634 mi1,020 km | 1h 42m |
| JAX JacksonvilleUnited States | Southwest Airlines | 9 | 753 mi1,212 km | 1h 53m |
| SAN San DiegoUnited States | Southwest Airlines | 9 | 1,557 mi2,506 km | 3h 47m |
| PDX PortlandUnited States | Alaska Airlines, Southwest Airlines | 9 | 1,708 mi2,749 km | 4h 3m |
| SMF SacramentoUnited States | Southwest Airlines | 8 | 1,679 mi2,702 km | 4h 3m |
| PNS PensacolaUnited States | Southwest Airlines | 8 | 598 mi962 km | 1h 40m |
| VPS ValparaisoUnited States | Southwest Airlines | 8 | 610 mi982 km | 1h 44m |
| SRQ Sarasota/BradentonUnited States | Southwest Airlines | 7 | 903 mi1,453 km | 2h 14m |
| CHS CharlestonUnited States | Southwest Airlines | 7 | 706 mi1,136 km | 1h 52m |
| SAV SavannahUnited States | Southwest Airlines | 7 | 689 mi1,109 km | 1h 48m |
| YUL MontréalCanada | Jazz Aviation | 6 | 970 mi1,561 km | 0m |
| JBR JonesboroUnited States | Southern Airways Express | 6 | 202 mi325 km | 1h 26m |
| MYR Myrtle BeachUnited States | Southwest Airlines | 6 | 728 mi1,172 km | 1h 49m |
| PUJ Punta CanaDominican Republic | Frontier Airlines, Southwest Airlines | 5 | 1,918 mi3,087 km | 4h 19m |
| FRA Frankfurt am MainGermany | Lufthansa | 5 | 4,592 mi7,390 km | 0m |
| LHR LondonUnited Kingdom | British Airways | 4 | 4,200 mi6,759 km | 0m |
| BUR BurbankUnited States | Southwest Airlines | 2 | 1,583 mi2,548 km | 3h 56m |
| SJU San JuanPuerto Rico | Southwest Airlines | <1 | 2,024 mi3,257 km | 4h 21m |
| MBJ Montego BayJamaica | Southwest Airlines | <1 | 1,583 mi2,548 km | 3h 34m |
| ORF NorfolkUnited States | Southwest Airlines | <1 | 785 mi1,263 km | 2h 0m |