| DEN DenverUnited States | Southwest Airlines, United Airlines, SkyWest Airlines, Frontier Airlines | 100 | 533 mi858 km | 1h 53m |
| ORD ChicagoUnited States | SkyWest Airlines, United Airlines, Envoy Air, Republic Airline | 85 | 403 mi649 km | 1h 45m |
| ATL AtlantaUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 65 | 692 mi1,114 km | 1h 56m |
| DFW Dallas-Fort WorthUnited States | American Airlines, SkyWest Airlines, Envoy Air | 51 | 460 mi740 km | 1h 47m |
| MDW ChicagoUnited States | Southwest Airlines | 47 | 404 mi650 km | 1h 19m |
| PHX PhoenixUnited States | Southwest Airlines, American Airlines | 41 | 1,044 mi1,680 km | 2h 49m |
| LAS Las VegasUnited States | Southwest Airlines, Frontier Airlines | 41 | 1,139 mi1,833 km | 2h 56m |
| DAL DallasUnited States | Southwest Airlines | 37 | 461 mi742 km | 1h 28m |
| LGA New YorkUnited States | Southwest Airlines, Delta Air Lines | 36 | 1,107 mi1,782 km | 2h 42m |
| DCA WashingtonUnited States | Southwest Airlines, PSA Airlines, Republic Airline | 34 | 949 mi1,527 km | 2h 23m |
| MSP MinneapolisUnited States | Delta Air Lines, Endeavor Air, SkyWest Airlines | 33 | 393 mi632 km | 1h 29m |
| LAX Los AngelesUnited States | Southwest Airlines, Delta Air Lines, SkyWest Airlines | 33 | 1,363 mi2,194 km | 3h 29m |
| AUS AustinUnited States | Southwest Airlines, SkyWest Airlines | 32 | 650 mi1,046 km | 1h 49m |
| BNA NashvilleUnited States | Southwest Airlines | 30 | 491 mi790 km | 1h 29m |
| MCO OrlandoUnited States | Southwest Airlines | 29 | 1,072 mi1,725 km | 2h 38m |
| SEA SeattleUnited States | Alaska Airlines, Delta Air Lines, Southwest Airlines | 29 | 1,490 mi2,398 km | 4h 0m |
| IAH HoustonUnited States | United Airlines, Mesa Airlines | 27 | 643 mi1,035 km | 2h 11m |
| DTW DetroitUnited States | Delta Air Lines | 26 | 629 mi1,012 km | 1h 47m |
| CLT CharlotteUnited States | American Airlines, PSA Airlines | 23 | 808 mi1,300 km | 2h 15m |
| STL St LouisUnited States | Southwest Airlines | 21 | 237 mi381 km | 56m |
| HOU HoustonUnited States | Southwest Airlines | 21 | 666 mi1,072 km | 1h 58m |
| MIA MiamiUnited States | American Airlines, Southwest Airlines, Envoy Air | 21 | 1,251 mi2,013 km | 3h 2m |
| SLC Salt Lake CityUnited States | Delta Air Lines | 20 | 920 mi1,481 km | 2h 39m |
| BWI BaltimoreUnited States | Southwest Airlines | 19 | 966 mi1,555 km | 2h 19m |
| PHL PhiladelphiaUnited States | American Airlines | 19 | 1,038 mi1,670 km | 2h 37m |
| BOS BostonUnited States | Delta Air Lines, Southwest Airlines | 19 | 1,256 mi2,021 km | 3h 0m |
| TPA TampaUnited States | Southwest Airlines | 14 | 1,048 mi1,687 km | 2h 28m |
| IAD DullesUnited States | United Airlines, Republic Airline | 13 | 926 mi1,490 km | 2h 28m |
| EWR NewarkUnited States | United Airlines, Republic Airline | 12 | 1,092 mi1,757 km | 2h 52m |
| CUN CancúnMexico | Southwest Airlines | 9 | 1,341 mi2,158 km | 3h 17m |
| PDX PortlandUnited States | Alaska Airlines, Southwest Airlines | 9 | 1,482 mi2,385 km | 3h 47m |
| RDU Raleigh/DurhamUnited States | Endeavor Air, Southwest Airlines | 8 | 904 mi1,455 km | 2h 23m |
| MKE MilwaukeeUnited States | Southwest Airlines | 8 | 436 mi702 km | 1h 22m |
| FLL Fort LauderdaleUnited States | Southwest Airlines | 8 | 1,242 mi1,999 km | 2h 54m |
| SAN San DiegoUnited States | Southwest Airlines | 8 | 1,334 mi2,147 km | 3h 19m |
| IND IndianapolisUnited States | Southwest Airlines | 7 | 451 mi726 km | 1h 19m |
| PNS PensacolaUnited States | Southwest Airlines | 7 | 743 mi1,196 km | 1h 56m |
| SMF SacramentoUnited States | Southwest Airlines | 7 | 1,442 mi2,321 km | 3h 33m |
| SFO San FranciscoUnited States | United Airlines | 7 | 1,499 mi2,412 km | 4h 1m |
| MSY New OrleansUnited States | Southwest Airlines | 6 | 690 mi1,110 km | 1h 49m |
| SAT San AntonioUnited States | Southwest Airlines | 6 | 706 mi1,136 km | 1h 55m |
| ECP Panama City BeachUnited States | Southwest Airlines | 6 | 797 mi1,283 km | 2h 2m |
| JFK New YorkUnited States | Endeavor Air | 6 | 1,113 mi1,791 km | 2h 52m |
| PIE Pinellas ParkUnited States | Allegiant Air | 4 | 1,045 mi1,682 km | 2h 34m |
| VPS ValparaisoUnited States | Allegiant Air, Southwest Airlines | 4 | 764 mi1,230 km | 2h 5m |
| PGD Punta GordaUnited States | Allegiant Air | 2 | 1,125 mi1,811 km | 2h 46m |
| MYR Myrtle BeachUnited States | Southwest Airlines | 2 | 959 mi1,543 km | 2h 14m |
| CMH ColumbusUnited States | Southwest Airlines | <1 | 632 mi1,017 km | 1h 43m |
| SRQ Sarasota/BradentonUnited States | Southwest Airlines | <1 | 1,078 mi1,735 km | 2h 40m |