| DEN DenverUnited States | Southwest Airlines, United Airlines, SkyWest Airlines, Frontier Airlines | 121 | 775 mi1,247 km | 2h 17m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Envoy Air, SkyWest Airlines, PSA Airlines | 97 | 190 mi306 km | 1h 14m |
| ATL AtlantaUnited States | Delta Air Lines, Southwest Airlines, Frontier Airlines | 87 | 813 mi1,308 km | 2h 11m |
| LAX Los AngelesUnited States | SkyWest Airlines, Delta Air Lines, Southwest Airlines, American Airlines | 82 | 1,242 mi1,999 km | 3h 15m |
| MCO OrlandoUnited States | Southwest Airlines, Delta Air Lines, Frontier Airlines | 65 | 994 mi1,600 km | 2h 32m |
| PHX PhoenixUnited States | Southwest Airlines, American Airlines, SkyWest Airlines | 60 | 872 mi1,403 km | 2h 26m |
| ORD ChicagoUnited States | United Airlines, American Airlines | 58 | 977 mi1,572 km | 2h 51m |
| LAS Las VegasUnited States | Southwest Airlines, Delta Air Lines, Frontier Airlines, Allegiant Air | 58 | 1,090 mi1,754 km | 2h 50m |
| IAH HoustonUnited States | United Airlines, Mesa Airlines | 57 | 140 mi225 km | 1h 8m |
| SFO San FranciscoUnited States | United Airlines, Delta Air Lines, Southwest Airlines | 56 | 1,504 mi2,420 km | 3h 49m |
| BNA NashvilleUnited States | Southwest Airlines, SkyWest Airlines | 54 | 756 mi1,217 km | 2h 5m |
| SEA SeattleUnited States | Alaska Airlines, Delta Air Lines, Southwest Airlines | 49 | 1,770 mi2,849 km | 4h 28m |
| SAN San DiegoUnited States | Southwest Airlines, SkyWest Airlines | 49 | 1,164 mi1,873 km | 3h 4m |
| MIA MiamiUnited States | American Airlines, Delta Air Lines, Southwest Airlines | 47 | 1,103 mi1,775 km | 2h 42m |
| DAL DallasUnited States | Southwest Airlines | 46 | 189 mi304 km | 59m |
| JFK New YorkUnited States | Delta Air Lines, American Airlines | 43 | 1,521 mi2,448 km | 3h 44m |
| BOS BostonUnited States | Delta Air Lines, JetBlue, Southwest Airlines | 39 | 1,698 mi2,733 km | 3h 58m |
| IND IndianapolisUnited States | Southwest Airlines, SkyWest Airlines | 39 | 919 mi1,479 km | 2h 24m |
| SLC Salt Lake CityUnited States | Delta Air Lines, Southwest Airlines, SkyWest Airlines | 38 | 1,086 mi1,748 km | 2h 54m |
| MSP MinneapolisUnited States | Delta Air Lines, SkyWest Airlines, Southwest Airlines | 33 | 1,042 mi1,677 km | 2h 43m |
| MCI Kansas CityUnited States | Southwest Airlines, SkyWest Airlines | 32 | 650 mi1,046 km | 1h 50m |
| MSY New OrleansUnited States | Southwest Airlines, SkyWest Airlines | 31 | 445 mi716 km | 1h 22m |
| EWR NewarkUnited States | United Airlines, Republic Airline | 30 | 1,504 mi2,420 km | 3h 38m |
| TPA TampaUnited States | Southwest Airlines, Delta Air Lines, SkyWest Airlines | 29 | 928 mi1,493 km | 2h 17m |
| MDW ChicagoUnited States | Southwest Airlines | 29 | 972 mi1,564 km | 2h 27m |
| CLT CharlotteUnited States | American Airlines | 27 | 1,032 mi1,661 km | 2h 40m |
| FLL Fort LauderdaleUnited States | JetBlue, Southwest Airlines | 26 | 1,105 mi1,778 km | 2h 41m |
| BWI BaltimoreUnited States | Southwest Airlines | 26 | 1,342 mi2,160 km | 3h 3m |
| RDU Raleigh/DurhamUnited States | Southwest Airlines, Endeavor Air | 26 | 1,162 mi1,870 km | 2h 51m |
| DTW DetroitUnited States | Delta Air Lines | 25 | 1,149 mi1,849 km | 2h 52m |
| IAD DullesUnited States | United Airlines, Mesa Airlines, Allegiant Air | 23 | 1,297 mi2,087 km | 3h 11m |
| ELP El PasoUnited States | Southwest Airlines | 22 | 528 mi850 km | 1h 33m |
| CUN CancúnMexico | Southwest Airlines, American Airlines | 21 | 921 mi1,482 km | 2h 28m |
| STL St LouisUnited States | Southwest Airlines | 20 | 721 mi1,160 km | 1h 58m |
| SJC San JoseUnited States | Southwest Airlines | 20 | 1,476 mi2,375 km | 3h 36m |
| ABQ AlbuquerqueUnited States | Southwest Airlines | 20 | 619 mi996 km | 1h 48m |
| PHL PhiladelphiaUnited States | American Airlines | 19 | 1,431 mi2,303 km | 3h 24m |
| MFE McAllenUnited States | SkyWest Airlines | 19 | 279 mi449 km | 1h 15m |
| HRL HarlingenUnited States | Southwest Airlines | 19 | 273 mi439 km | 1h 0m |
| HOU HoustonUnited States | Southwest Airlines | 18 | 148 mi238 km | 59m |
| CVG Cincinnati / CovingtonUnited States | Endeavor Air, Southwest Airlines, Allegiant Air | 16 | 958 mi1,542 km | 2h 30m |
| JAX JacksonvilleUnited States | Southwest Airlines, SkyWest Airlines | 14 | 953 mi1,534 km | 2h 24m |
| PDX PortlandUnited States | Alaska Airlines | 14 | 1,715 mi2,760 km | 4h 10m |
| CMH ColumbusUnited States | SkyWest Airlines, Southwest Airlines | 14 | 1,073 mi1,727 km | 2h 37m |
| ECP Panama City BeachUnited States | Southwest Airlines, SkyWest Airlines | 13 | 710 mi1,143 km | 1h 59m |
| LHR LondonUnited Kingdom | British Airways | 13 | 4,915 mi7,910 km | 0m |
| SJD San José del CaboMexico | American Airlines, Southwest Airlines | 10 | 888 mi1,429 km | 2h 34m |
| PIT PittsburghUnited States | Southwest Airlines, Allegiant Air | 8 | 1,210 mi1,947 km | 2h 50m |
| MEM MemphisUnited States | SkyWest Airlines | 7 | 559 mi900 km | 1h 46m |
| SMF SacramentoUnited States | Southwest Airlines | 7 | 1,481 mi2,383 km | 3h 38m |
| OAK OaklandUnited States | Southwest Airlines | 7 | 1,497 mi2,409 km | 3h 40m |
| SNA Santa AnaUnited States | Southwest Airlines | 7 | 1,209 mi1,946 km | 3h 4m |
| PNS PensacolaUnited States | Southwest Airlines | 7 | 626 mi1,007 km | 1h 44m |
| LGB Long BeachUnited States | Southwest Airlines | 7 | 1,226 mi1,973 km | 3h 4m |
| YYZ TorontoCanada | Air Canada Rouge, Air Canada | 7 | 1,359 mi2,187 km | 0m |
| BUR BurbankUnited States | Southwest Airlines | 7 | 1,241 mi1,997 km | 3h 11m |
| ONT OntarioUnited States | Southwest Airlines | 7 | 1,196 mi1,925 km | 2h 59m |
| OKC Oklahoma CityUnited States | Southwest Airlines | 7 | 358 mi576 km | 1h 13m |
| TUL TulsaUnited States | Southwest Airlines | 7 | 426 mi686 km | 1h 21m |
| ASE AspenUnited States | SkyWest Airlines | 7 | 812 mi1,307 km | 2h 46m |
| MAF MidlandUnited States | Southwest Airlines | 7 | 294 mi473 km | 1h 8m |
| CHS CharlestonUnited States | Southwest Airlines | 7 | 1,055 mi1,698 km | 2h 33m |
| LBB LubbockUnited States | Southwest Airlines | 6 | 341 mi549 km | 1h 9m |
| DCA WashingtonUnited States | Southwest Airlines | 6 | 1,315 mi2,116 km | 3h 5m |
| MKE MilwaukeeUnited States | Southwest Airlines | 6 | 1,032 mi1,661 km | 2h 34m |
| PTY TocumenPanama | Copa Airlines | 5 | 1,873 mi3,014 km | 0m |
| MTY MonterreyMexico | Viva | 5 | 339 mi546 km | 0m |
| FRA Frankfurt am MainGermany | Lufthansa | 5 | 5,309 mi8,544 km | 0m |
| AMA AmarilloUnited States | Southwest Airlines | 4 | 419 mi674 km | 1h 19m |
| RNO RenoUnited States | Southwest Airlines | 4 | 1,405 mi2,261 km | 3h 28m |
| YUL MontréalCanada | Air Canada Rouge | 4 | 1,669 mi2,686 km | 0m |
| YVR VancouverCanada | Air Canada Rouge, Air Canada | 4 | 1,872 mi3,013 km | 0m |
| AMS AmsterdamNetherlands | KLM | 3 | 5,089 mi8,190 km | 0m |
| PVU ProvoUnited States | Allegiant Air | 2 | 1,051 mi1,691 km | 2h 50m |
| DSM Des MoinesUnited States | Allegiant Air | 2 | 813 mi1,308 km | 2h 11m |
| GRR Grand RapidsUnited States | Allegiant Air | 2 | 1,103 mi1,775 km | 2h 41m |
| TYS Knoxville/MaryvilleUnited States | Allegiant Air | 2 | 882 mi1,419 km | 2h 16m |
| YYC CalgaryCanada | WestJet | 2 | 1,671 mi2,689 km | 0m |
| SRQ Sarasota/BradentonUnited States | Allegiant Air | 2 | 936 mi1,506 km | 2h 27m |
| AVL AshevilleUnited States | Allegiant Air | 2 | 950 mi1,529 km | 2h 27m |
| SFB OrlandoUnited States | Allegiant Air | 2 | 994 mi1,600 km | 2h 40m |
| SJU San JuanPuerto Rico | Southwest Airlines | <1 | 2,146 mi3,454 km | 4h 29m |