| ORD ChicagoUnited States | United Airlines, American Airlines, Delta Air Lines, Republic Airline | 200 | 733 mi1,180 km | 2h 45m |
| BOS BostonUnited States | Republic Airline, Delta Air Lines | 138 | 184 mi296 km | 1h 17m |
| ATL AtlantaUnited States | Delta Air Lines, Republic Airline, Frontier Airlines | 137 | 762 mi1,226 km | 2h 29m |
| YYZ TorontoCanada | Air Canada, Endeavor Air, Republic Airline, Jazz Aviation | 119 | 357 mi575 km | 50m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Delta Air Lines, Frontier Airlines | 113 | 1,389 mi2,235 km | 3h 57m |
| MIA MiamiUnited States | American Airlines, Delta Air Lines | 97 | 1,096 mi1,764 km | 3h 11m |
| CLT CharlotteUnited States | American Airlines, Endeavor Air, Republic Airline, Frontier Airlines | 88 | 544 mi875 km | 2h 4m |
| DEN DenverUnited States | United Airlines, Southwest Airlines, Delta Air Lines | 82 | 1,620 mi2,607 km | 4h 23m |
| DCA WashingtonUnited States | Republic Airline, Delta Air Lines | 82 | 214 mi344 km | 1h 29m |
| BNA NashvilleUnited States | Southwest Airlines, Republic Airline, Endeavor Air, American Airlines, Delta Air Lines | 75 | 764 mi1,230 km | 2h 32m |
| IAH HoustonUnited States | United Airlines, Delta Air Lines | 74 | 1,416 mi2,279 km | 3h 55m |
| FLL Fort LauderdaleUnited States | JetBlue, Delta Air Lines, American Airlines | 73 | 1,076 mi1,732 km | 3h 6m |
| MCO OrlandoUnited States | Delta Air Lines, JetBlue, American Airlines, Frontier Airlines | 71 | 950 mi1,529 km | 2h 55m |
| RDU Raleigh/DurhamUnited States | Endeavor Air, Republic Airline, American Airlines | 66 | 431 mi694 km | 1h 51m |
| STL St LouisUnited States | Southwest Airlines, Endeavor Air, Republic Airline | 62 | 888 mi1,429 km | 2h 46m |
| YUL MontréalCanada | Jazz Aviation, Endeavor Air, Air Canada, Republic Airline | 58 | 324 mi521 km | 35m |
| PIT PittsburghUnited States | Republic Airline | 56 | 335 mi539 km | 1h 34m |
| DTW DetroitUnited States | Delta Air Lines, Republic Airline | 53 | 502 mi808 km | 1h 57m |
| IND IndianapolisUnited States | Republic Airline, Endeavor Air | 53 | 660 mi1,062 km | 2h 19m |
| CMH ColumbusUnited States | Republic Airline, Endeavor Air | 51 | 479 mi771 km | 1h 53m |
| RIC RichmondUnited States | Republic Airline, Endeavor Air | 48 | 291 mi468 km | 1h 34m |
| CLE ClevelandUnited States | Endeavor Air, Republic Airline | 48 | 419 mi674 km | 1h 48m |
| MDW ChicagoUnited States | Southwest Airlines | 42 | 725 mi1,167 km | 2h 21m |
| CHS CharlestonUnited States | Republic Airline, Endeavor Air, Delta Air Lines | 41 | 641 mi1,032 km | 2h 16m |
| TPA TampaUnited States | Delta Air Lines, American Airlines | 41 | 1,010 mi1,625 km | 3h 0m |
| BUF BuffaloUnited States | Endeavor Air, Republic Airline | 40 | 292 mi470 km | 1h 27m |
| ORF NorfolkUnited States | Endeavor Air, Republic Airline | 38 | 296 mi476 km | 1h 29m |
| MCI Kansas CityUnited States | Southwest Airlines, Delta Air Lines, Endeavor Air | 37 | 1,107 mi1,782 km | 3h 16m |
| GSO GreensboroUnited States | Republic Airline, Endeavor Air | 37 | 461 mi742 km | 1h 51m |
| GSP Greenville/Greer/SpartanburgUnited States | Endeavor Air, Republic Airline | 35 | 610 mi982 km | 2h 11m |
| PWM PortlandUnited States | Republic Airline, Endeavor Air, American Airlines | 35 | 269 mi433 km | 1h 21m |
| ILM WilmingtonUnited States | Endeavor Air, Republic Airline | 33 | 500 mi805 km | 1h 55m |
| CVG Cincinnati / CovingtonUnited States | Endeavor Air | 33 | 585 mi941 km | 2h 11m |
| MSP MinneapolisUnited States | Delta Air Lines | 32 | 1,020 mi1,642 km | 3h 2m |
| BGR BangorUnited States | Endeavor Air, Republic Airline | 30 | 378 mi608 km | 1h 30m |
| DAL DallasUnited States | Southwest Airlines | 30 | 1,381 mi2,223 km | 3h 44m |
| MEM MemphisUnited States | Republic Airline, Endeavor Air | 28 | 963 mi1,550 km | 2h 58m |
| ACK NantucketUnited States | Republic Airline, JetBlue | 25 | 202 mi325 km | 1h 13m |
| MSY New OrleansUnited States | Delta Air Lines, American Airlines, Southwest Airlines | 25 | 1,183 mi1,904 km | 3h 21m |
| JAX JacksonvilleUnited States | Republic Airline, Endeavor Air | 25 | 834 mi1,342 km | 2h 38m |
| IAD DullesUnited States | Mesa Airlines, Republic Airline | 24 | 228 mi367 km | 1h 24m |
| YTZ TorontoCanada | Jazz Aviation | 24 | 345 mi555 km | 0m |
| SDF LouisvilleUnited States | Republic Airline, Endeavor Air | 24 | 659 mi1,061 km | 2h 23m |
| GRR Grand RapidsUnited States | Republic Airline, Endeavor Air | 23 | 618 mi995 km | 2h 11m |
| HOU HoustonUnited States | Southwest Airlines | 23 | 1,428 mi2,298 km | 3h 53m |
| MKE MilwaukeeUnited States | Republic Airline | 23 | 738 mi1,188 km | 2h 30m |
| CAE ColumbiaUnited States | Endeavor Air, Republic Airline | 23 | 617 mi993 km | 2h 8m |
| OMA OmahaUnited States | Endeavor Air, Southwest Airlines | 22 | 1,148 mi1,848 km | 3h 21m |
| MVY Martha's VineyardUnited States | Republic Airline | 22 | 175 mi282 km | 1h 4m |
| XNA Fayetteville/Springdale/RogersUnited States | Republic Airline, Endeavor Air | 21 | 1,147 mi1,846 km | 3h 25m |
| AVL AshevilleUnited States | Endeavor Air, Republic Airline | 21 | 599 mi964 km | 2h 9m |
| YHZ HalifaxCanada | Endeavor Air, Republic Airline | 20 | 598 mi962 km | 1h 56m |
| SAV SavannahUnited States | Endeavor Air, Republic Airline | 20 | 722 mi1,162 km | 2h 27m |
| MSN MadisonUnited States | Republic Airline, Endeavor Air | 18 | 812 mi1,307 km | 2h 37m |
| TYS Knoxville/MaryvilleUnited States | Endeavor Air | 18 | 647 mi1,041 km | 2h 15m |
| BHM BirminghamUnited States | Endeavor Air | 18 | 866 mi1,394 km | 2h 42m |
| TUL TulsaUnited States | Republic Airline, Endeavor Air | 17 | 1,231 mi1,981 km | 3h 34m |
| CHO CharlottesvilleUnited States | Endeavor Air, Republic Airline | 17 | 305 mi491 km | 1h 28m |
| ROC RochesterUnited States | Endeavor Air | 16 | 254 mi409 km | 1h 25m |
| SYR SyracuseUnited States | Endeavor Air, Republic Airline | 16 | 198 mi319 km | 1h 17m |
| OKC Oklahoma CityUnited States | Republic Airline, Endeavor Air | 16 | 1,341 mi2,158 km | 3h 50m |
| ROA RoanokeUnited States | Republic Airline, Endeavor Air | 12 | 405 mi652 km | 1h 47m |
| BTV BurlingtonUnited States | Endeavor Air | 12 | 258 mi415 km | 1h 18m |
| ALB AlbanyUnited States | Endeavor Air | 12 | 136 mi219 km | 1h 3m |
| RSW Fort MyersUnited States | Delta Air Lines | 11 | 1,080 mi1,738 km | 3h 13m |
| LEX LexingtonUnited States | Republic Airline, Endeavor Air | 11 | 604 mi972 km | 2h 9m |
| DSM Des MoinesUnited States | Endeavor Air, Republic Airline | 11 | 1,031 mi1,659 km | 3h 10m |
| CHA ChattanoogaUnited States | Endeavor Air | 11 | 734 mi1,181 km | 2h 25m |
| HSV HuntsvilleUnited States | Endeavor Air | 11 | 823 mi1,324 km | 2h 40m |
| LIT Little RockUnited States | Endeavor Air, Republic Airline | 10 | 1,085 mi1,746 km | 3h 20m |
| MYR Myrtle BeachUnited States | Delta Air Lines, Republic Airline | 10 | 563 mi906 km | 1h 58m |
| TVC Traverse CityUnited States | Republic Airline, Endeavor Air | 8 | 655 mi1,054 km | 2h 16m |
| HHH Hilton Head IslandUnited States | Republic Airline | 7 | 701 mi1,128 km | 2h 20m |
| HYA HyannisUnited States | Republic Airline | 6 | 197 mi317 km | 1h 10m |
| PNS PensacolaUnited States | Endeavor Air | 6 | 1,030 mi1,658 km | 3h 4m |
| SRQ Sarasota/BradentonUnited States | Delta Air Lines | 6 | 1,047 mi1,685 km | 3h 7m |
| ORH WorcesterUnited States | Endeavor Air | 5 | 146 mi235 km | 1h 9m |
| ECP Panama City BeachUnited States | Endeavor Air | 2 | 981 mi1,579 km | 3h 4m |
| VPS ValparaisoUnited States | Endeavor Air | 1 | 1,003 mi1,614 km | 3h 8m |