| ATL AtlantaUnited States | Delta Air Lines, Frontier Airlines | 86 | 269 mi433 km | 1h 12m |
| ORD ChicagoUnited States | American Airlines, United Airlines, SkyWest Airlines, Republic Airline | 45 | 864 mi1,390 km | 2h 48m |
| DFW Dallas-Fort WorthUnited States | American Airlines | 40 | 917 mi1,476 km | 2h 47m |
| CLT CharlotteUnited States | American Airlines | 34 | 328 mi528 km | 1h 23m |
| PHL PhiladelphiaUnited States | American Airlines, Frontier Airlines, PSA Airlines | 33 | 742 mi1,194 km | 2h 7m |
| BOS BostonUnited States | Republic Airline, JetBlue | 32 | 1,011 mi1,627 km | 2h 39m |
| JFK New YorkUnited States | Endeavor Air, JetBlue, Delta Air Lines | 29 | 829 mi1,334 km | 2h 19m |
| MIA MiamiUnited States | Envoy Air, American Airlines | 28 | 335 mi539 km | 1h 20m |
| IAH HoustonUnited States | Mesa Airlines, United Airlines | 28 | 816 mi1,313 km | 2h 27m |
| DCA WashingtonUnited States | American Airlines, PSA Airlines, Republic Airline | 26 | 634 mi1,020 km | 1h 54m |
| EWR NewarkUnited States | United Airlines, Republic Airline | 25 | 820 mi1,320 km | 2h 19m |
| LGA New YorkUnited States | Republic Airline, Endeavor Air | 25 | 834 mi1,342 km | 2h 18m |
| BWI BaltimoreUnited States | Southwest Airlines | 23 | 663 mi1,067 km | 1h 48m |
| BNA NashvilleUnited States | Southwest Airlines, Allegiant Air | 23 | 483 mi777 km | 1h 34m |
| DEN DenverUnited States | United Airlines, Southwest Airlines | 19 | 1,446 mi2,327 km | 3h 48m |
| FLL Fort LauderdaleUnited States | JetBlue, Breeze Airways | 17 | 319 mi513 km | 1h 19m |
| IAD DullesUnited States | United Airlines, Allegiant Air | 16 | 631 mi1,015 km | 1h 48m |
| SJU San JuanPuerto Rico | JetBlue, Frontier Airlines | 14 | 1,288 mi2,073 km | 3h 1m |
| AUS AustinUnited States | SkyWest Airlines, Southwest Airlines | 14 | 953 mi1,534 km | 2h 44m |
| MDW ChicagoUnited States | Southwest Airlines | 13 | 848 mi1,365 km | 2h 19m |
| DTW DetroitUnited States | Delta Air Lines | 12 | 813 mi1,308 km | 2h 14m |
| MSP MinneapolisUnited States | Delta Air Lines, Sun Country Airlines | 9 | 1,173 mi1,888 km | 3h 5m |
| STL St LouisUnited States | Southwest Airlines | 9 | 753 mi1,212 km | 2h 6m |
| MCO OrlandoUnited States | Southwest Airlines, American Airlines, Delta Air Lines, United Airlines | 7 | 144 mi232 km | 1h 5m |
| ORF NorfolkUnited States | Breeze Airways | 7 | 543 mi874 km | 1h 39m |
| HOU HoustonUnited States | Southwest Airlines | 7 | 815 mi1,312 km | 2h 17m |
| DAL DallasUnited States | Southwest Airlines | 7 | 906 mi1,458 km | 2h 30m |
| CAK AkronUnited States | Allegiant Air, Breeze Airways | 7 | 719 mi1,157 km | 2h 5m |
| PIT PittsburghUnited States | Allegiant Air, Breeze Airways | 6 | 694 mi1,117 km | 1h 55m |
| PHX PhoenixUnited States | American Airlines | 6 | 1,785 mi2,873 km | 4h 32m |
| HVN New HavenUnited States | Breeze Airways, Avelo Airlines | 4 | 891 mi1,434 km | 2h 24m |
| YYZ TorontoCanada | Air Canada | 4 | 916 mi1,474 km | 0m |
| CVG Cincinnati / CovingtonUnited States | Allegiant Air | 3 | 613 mi987 km | 1h 50m |
| RDU Raleigh/DurhamUnited States | Breeze Airways | 3 | 408 mi657 km | 1h 28m |
| LAX Los AngelesUnited States | Breeze Airways | 3 | 2,152 mi3,463 km | 5h 17m |
| BDL HartfordUnited States | Breeze Airways | 2 | 935 mi1,505 km | 2h 31m |
| TYS Knoxville/MaryvilleUnited States | Allegiant Air | 2 | 390 mi628 km | 1h 20m |
| GRR Grand RapidsUnited States | Allegiant Air | 2 | 880 mi1,416 km | 2h 18m |
| LAS Las VegasUnited States | Breeze Airways | 2 | 1,964 mi3,161 km | 4h 56m |
| IND IndianapolisUnited States | Allegiant Air | 2 | 687 mi1,106 km | 1h 58m |
| CMH ColumbusUnited States | Breeze Airways | 2 | 658 mi1,059 km | 2h 0m |
| FNT FlintUnited States | Allegiant Air | 2 | 867 mi1,395 km | 2h 21m |
| MDT HarrisburgUnited States | Allegiant Air | 2 | 724 mi1,165 km | 2h 1m |
| RIC RichmondUnited States | Breeze Airways | 2 | 545 mi877 km | 1h 43m |
| BLV BellevilleUnited States | Allegiant Air | 2 | 723 mi1,164 km | 2h 4m |
| SAN San DiegoUnited States | Breeze Airways | 2 | 2,088 mi3,360 km | 5h 1m |
| PVD Providence/WarwickUnited States | Breeze Airways | 2 | 963 mi1,550 km | 2h 28m |
| DSM Des MoinesUnited States | Allegiant Air | 2 | 1,012 mi1,629 km | 2h 37m |