| ORD ChicagoUnited States | United Airlines, American Airlines, Delta Air Lines, JetBlue, Envoy Air, Republic Airline | 169 | 867 mi1,395 km | 2h 58m |
| DCA WashingtonUnited States | Republic Airline, JetBlue, American Airlines, Envoy Air | 154 | 399 mi642 km | 1h 48m |
| LGA New YorkUnited States | Republic Airline, Delta Air Lines | 136 | 184 mi296 km | 1h 21m |
| ACK NantucketUnited States | Cape Air, JetBlue, Republic Airline | 123 | 91 mi146 km | 34m |
| SFO San FranciscoUnited States | JetBlue, United Airlines, Delta Air Lines | 111 | 2,704 mi4,352 km | 6h 35m |
| LAX Los AngelesUnited States | JetBlue, American Airlines, Delta Air Lines, United Airlines | 106 | 2,611 mi4,202 km | 6h 20m |
| ATL AtlantaUnited States | Delta Air Lines, JetBlue, Frontier Airlines | 102 | 946 mi1,522 km | 2h 49m |
| PHL PhiladelphiaUnited States | American Airlines, Republic Airline, JetBlue | 92 | 280 mi451 km | 1h 33m |
| JFK New YorkUnited States | Republic Airline, JetBlue, Delta Air Lines, American Airlines | 86 | 187 mi301 km | 1h 20m |
| DEN DenverUnited States | United Airlines, Southwest Airlines, JetBlue, Delta Air Lines | 86 | 1,754 mi2,823 km | 4h 35m |
| CLT CharlotteUnited States | American Airlines, Republic Airline | 78 | 728 mi1,172 km | 2h 24m |
| MVY Martha's VineyardUnited States | Cape Air, JetBlue | 77 | 70 mi113 km | 35m |
| MCO OrlandoUnited States | JetBlue, Delta Air Lines, American Airlines, Frontier Airlines | 75 | 1,121 mi1,804 km | 3h 15m |
| DFW Dallas-Fort WorthUnited States | American Airlines, Delta Air Lines | 73 | 1,562 mi2,514 km | 4h 18m |
| SEA SeattleUnited States | Alaska Airlines, Delta Air Lines, JetBlue | 70 | 2,496 mi4,017 km | 6h 19m |
| BWI BaltimoreUnited States | Southwest Airlines, Republic Airline | 68 | 369 mi594 km | 1h 31m |
| EWR NewarkUnited States | United Airlines, Republic Airline | 63 | 200 mi322 km | 1h 26m |
| BNA NashvilleUnited States | Southwest Airlines, JetBlue, Delta Air Lines, Republic Airline | 60 | 942 mi1,516 km | 2h 50m |
| MIA MiamiUnited States | American Airlines, Delta Air Lines | 59 | 1,258 mi2,025 km | 3h 31m |
| LHR LondonUnited Kingdom | British Airways, Virgin Atlantic, JetBlue, Delta Air Lines, American Airlines | 55 | 3,265 mi5,255 km | 2h 40m |
| MSP MinneapolisUnited States | Delta Air Lines, Sun Country Airlines | 52 | 1,124 mi1,809 km | 3h 14m |
| RDU Raleigh/DurhamUnited States | Delta Air Lines, JetBlue, Frontier Airlines | 51 | 612 mi985 km | 2h 4m |
| DTW DetroitUnited States | Delta Air Lines, JetBlue | 51 | 632 mi1,017 km | 2h 9m |
| BHB Bar HarborUnited States | Cape Air | 48 | 196 mi315 km | 1h 12m |
| SAN San DiegoUnited States | JetBlue, Alaska Airlines, Delta Air Lines, Southwest Airlines | 47 | 2,588 mi4,165 km | 6h 15m |
| PIT PittsburghUnited States | Republic Airline, JetBlue | 46 | 496 mi798 km | 1h 51m |
| TPA TampaUnited States | JetBlue, Delta Air Lines | 45 | 1,185 mi1,907 km | 3h 18m |
| IAH HoustonUnited States | United Airlines, JetBlue | 45 | 1,597 mi2,570 km | 4h 15m |
| CVG Cincinnati / CovingtonUnited States | Republic Airline, Envoy Air | 43 | 752 mi1,210 km | 2h 28m |
| HYA HyannisUnited States | Cape Air | 41 | 61 mi98 km | 35m |
| RKD RocklandUnited States | Cape Air | 40 | 152 mi245 km | 1h 3m |
| FLL Fort LauderdaleUnited States | JetBlue, Delta Air Lines | 40 | 1,237 mi1,991 km | 3h 26m |
| IND IndianapolisUnited States | Republic Airline, Allegiant Air | 40 | 818 mi1,316 km | 2h 39m |
| AUS AustinUnited States | Delta Air Lines, JetBlue, Southwest Airlines | 39 | 1,698 mi2,733 km | 4h 28m |
| BUF BuffaloUnited States | JetBlue, Republic Airline, Envoy Air | 39 | 395 mi636 km | 1h 32m |
| CMH ColumbusUnited States | Republic Airline, Envoy Air | 37 | 640 mi1,030 km | 2h 15m |
| IAD DullesUnited States | United Airlines, Republic Airline | 37 | 412 mi663 km | 1h 40m |
| YYZ TorontoCanada | Air Canada, Jazz Aviation | 33 | 446 mi718 km | 0m |
| MDW ChicagoUnited States | Southwest Airlines | 33 | 861 mi1,386 km | 2h 34m |
| PHX PhoenixUnited States | American Airlines, Delta Air Lines | 33 | 2,300 mi3,701 km | 5h 44m |
| STL St LouisUnited States | Southwest Airlines, Republic Airline, Envoy Air | 32 | 1,047 mi1,685 km | 3h 1m |
| JAX JacksonvilleUnited States | Republic Airline, JetBlue, Delta Air Lines | 31 | 1,011 mi1,627 km | 2h 57m |
| RIC RichmondUnited States | Republic Airline, JetBlue | 30 | 473 mi761 km | 1h 51m |
| CLE ClevelandUnited States | Republic Airline, JetBlue | 30 | 563 mi906 km | 2h 3m |
| DUB DublinIreland | Aer Lingus, JetBlue, Delta Air Lines | 30 | 2,993 mi4,817 km | 2h 15m |
| CDG Paris (Roissy-en-France, Val-d'Oise)France | Air France, Delta Air Lines, JetBlue | 28 | 3,449 mi5,551 km | 3h 58m |
| LEB LebanonUnited States | Cape Air | 27 | 109 mi175 km | 48m |
| SLC Salt Lake CityUnited States | Delta Air Lines, JetBlue | 27 | 2,105 mi3,388 km | 5h 23m |
| AUG AugustaUnited States | Cape Air | 27 | 148 mi238 km | 1h 8m |
| SJU San JuanPuerto Rico | JetBlue, Delta Air Lines | 27 | 1,674 mi2,694 km | 4h 1m |
| MAD MadridSpain | Iberia, JetBlue, Delta Air Lines | 27 | 3,410 mi5,488 km | 2h 17m |
| AMS AmsterdamNetherlands | Delta Air Lines, JetBlue, KLM | 25 | 3,457 mi5,564 km | 5h 38m |
| YUL MontréalCanada | Air Canada, Jazz Aviation | 25 | 254 mi409 km | 0m |
| PDX PortlandUnited States | Alaska Airlines, JetBlue | 25 | 2,537 mi4,083 km | 6h 11m |
| CHS CharlestonUnited States | JetBlue, Delta Air Lines, Republic Airline | 21 | 818 mi1,316 km | 2h 33m |
| MSS MassenaUnited States | Boutique Air | 21 | 262 mi422 km | 46m |
| LAS Las VegasUnited States | JetBlue, Delta Air Lines | 21 | 2,381 mi3,832 km | 5h 53m |
| RUT RutlandUnited States | Cape Air | 21 | 127 mi204 km | 1h 14m |
| ISP IslipUnited States | Cape Air | 21 | 153 mi246 km | 59m |
| LIS LisbonPortugal | TAP Air Portugal, Delta Air Lines | 20 | 3,192 mi5,137 km | 2h 2m |
| RSW Fort MyersUnited States | JetBlue, Delta Air Lines | 19 | 1,249 mi2,010 km | 3h 31m |
| AUA OranjestadAruba | JetBlue, Delta Air Lines | 19 | 2,057 mi3,310 km | 4h 49m |
| MCI Kansas CityUnited States | Delta Air Lines, Southwest Airlines | 19 | 1,256 mi2,021 km | 3h 35m |
| MKE MilwaukeeUnited States | Republic Airline, JetBlue | 19 | 860 mi1,384 km | 2h 38m |
| ROC RochesterUnited States | Republic Airline, Envoy Air | 18 | 343 mi552 km | 1h 31m |
| YTZ TorontoCanada | Jazz Aviation | 18 | 434 mi698 km | 0m |
| SDQ Santo DomingoDominican Republic | JetBlue, Arajet | 18 | 1,651 mi2,657 km | 3h 33m |
| SAV SavannahUnited States | Republic Airline, JetBlue | 17 | 901 mi1,450 km | 2h 43m |
| BCN BarcelonaSpain | Delta Air Lines, JetBlue, Level | 17 | 3,650 mi5,874 km | 3h 16m |
| TVC Traverse CityUnited States | Republic Airline, JetBlue | 16 | 749 mi1,205 km | 2h 25m |
| ORF NorfolkUnited States | Republic Airline, JetBlue | 15 | 468 mi753 km | 1h 44m |
| ILM WilmingtonUnited States | Republic Airline, JetBlue | 15 | 672 mi1,081 km | 2h 8m |
| SLK Saranac LakeUnited States | Cape Air | 14 | 213 mi343 km | 1h 24m |
| CUN CancúnMexico | JetBlue, Delta Air Lines | 14 | 1,734 mi2,791 km | 4h 37m |
| KEF ReykjavÃkIceland | Icelandair | 14 | 2,413 mi3,883 km | 0m |
| ZRH ZurichSwitzerland | Swiss International Air Lines | 14 | 3,745 mi6,027 km | 0m |
| PUJ Punta CanaDominican Republic | JetBlue | 14 | 1,646 mi2,649 km | 4h 5m |
| SDF LouisvilleUnited States | Republic Airline, Envoy Air | 14 | 829 mi1,334 km | 2h 38m |
| FRA Frankfurt am MainGermany | Lufthansa | 14 | 3,669 mi5,905 km | 0m |
| MSY New OrleansUnited States | JetBlue, Delta Air Lines | 14 | 1,367 mi2,200 km | 3h 41m |
| SYR SyracuseUnited States | Republic Airline, JetBlue | 14 | 265 mi426 km | 1h 16m |
| PTY TocumenPanama | Copa Airlines | 14 | 2,348 mi3,779 km | 0m |
| BDA HamiltonBermuda | BermudAir, JetBlue | 14 | 772 mi1,242 km | 1h 13m |
| EDI Ingliston, EdinburghUnited Kingdom | Delta Air Lines, JetBlue | 14 | 3,069 mi4,939 km | 6h 17m |
| STI SantiagoDominican Republic | JetBlue | 13 | 1,582 mi2,546 km | 3h 54m |
| MSN MadisonUnited States | Republic Airline | 13 | 932 mi1,500 km | 2h 45m |
| MXP Ferno (VA)Italy | JetBlue, Delta Air Lines | 11 | 3,810 mi6,132 km | 7h 36m |
| YYC CalgaryCanada | WestJet | 10 | 2,097 mi3,375 km | 0m |
| PDL Ponta DelgadaPortugal | Azores Airlines | 9 | 2,395 mi3,854 km | 0m |
| SNN ShannonIreland | Aer Lingus | 8 | 2,895 mi4,659 km | 0m |
| BZN BozemanUnited States | JetBlue, Delta Air Lines | 8 | 1,991 mi3,204 km | 5h 10m |
| FCO RomeItaly | Delta Air Lines | 7 | 4,093 mi6,587 km | 5h 37m |
| NRT NaritaJapan | Japan Airlines | 7 | 6,701 mi10,784 km | 0m |
| HKG Hong KongHong Kong | Cathay Pacific | 7 | 7,968 mi12,823 km | 0m |
| ICN SeoulSouth Korea | Korean Air | 7 | 6,829 mi10,990 km | 0m |
| SAT San AntonioUnited States | Delta Air Lines | 7 | 1,764 mi2,839 km | 4h 36m |
| MUC MunichGermany | Lufthansa | 7 | 3,852 mi6,199 km | 0m |
| CPH CopenhagenDenmark | Scandinavian Airlines | 7 | 3,670 mi5,906 km | 0m |
| IST IstanbulTurkey | Turkish Airlines | 7 | 4,812 mi7,744 km | 0m |
| ATH Spata-ArtemidaGreece | Delta Air Lines | 7 | 4,755 mi7,652 km | 9h 1m |
| DAL DallasUnited States | Southwest Airlines | 7 | 1,554 mi2,501 km | 4h 2m |
| DAB Daytona BeachUnited States | JetBlue | 7 | 1,068 mi1,719 km | 3h 2m |
| SAL San Salvador (San Luis Talpa)El Salvador | Avianca El Salvador | 7 | 2,266 mi3,647 km | 0m |
| LGW LondonUnited Kingdom | JetBlue | 7 | 3,283 mi5,283 km | 6h 41m |
| PQI Presque IsleUnited States | JetBlue | 7 | 332 mi534 km | 1h 14m |
| MDT HarrisburgUnited States | Republic Airline | 6 | 335 mi539 km | 1h 39m |
| MEM MemphisUnited States | Republic Airline | 6 | 1,139 mi1,833 km | 3h 17m |
| VRB Vero BeachUnited States | JetBlue | 6 | 1,144 mi1,841 km | 3h 16m |
| YVR VancouverCanada | JetBlue | 6 | 2,514 mi4,046 km | 4h 0m |
| AUH Abu DhabiUnited Arab Emirates | Etihad Airways | 6 | 6,680 mi10,750 km | 0m |
| AVL AshevilleUnited States | Allegiant Air, Republic Airline | 6 | 783 mi1,260 km | 2h 21m |
| VPS ValparaisoUnited States | JetBlue, Allegiant Air | 5 | 1,187 mi1,910 km | 3h 15m |
| GRU São PauloBrazil | LATAM Airlines Brasil | 4 | 4,790 mi7,709 km | 0m |
| TLV Tel AvivIsrael | El Al | 4 | 5,492 mi8,839 km | 0m |
| SRQ Sarasota/BradentonUnited States | Allegiant Air, JetBlue | 4 | 1,220 mi1,963 km | 3h 29m |
| MYR Myrtle BeachUnited States | Envoy Air, Delta Air Lines | 4 | 738 mi1,188 km | 2h 16m |
| MBJ Montego BayJamaica | JetBlue | 4 | 1,693 mi2,725 km | 4h 21m |
| OPO PortoPortugal | TAP Air Portugal | 4 | 3,144 mi5,060 km | 0m |
| TYS Knoxville/MaryvilleUnited States | Allegiant Air | 3 | 830 mi1,336 km | 2h 27m |
| PEK BeijingChina | Hainan Airlines | 3 | 6,737 mi10,842 km | 0m |
| BOG BogotaColombia | Avianca | 3 | 2,599 mi4,183 km | 0m |
| NCE Nice, Alpes-MaritimesFrance | Delta Air Lines | 3 | 3,807 mi6,127 km | 7h 27m |
| STT Charlotte AmalieU.S. Virgin Islands | JetBlue | 3 | 1,693 mi2,725 km | 4h 5m |
| DSM Des MoinesUnited States | Allegiant Air | 2 | 1,165 mi1,875 km | 3h 9m |
| GRR Grand RapidsUnited States | Allegiant Air | 2 | 740 mi1,191 km | 2h 16m |
| YHZ HalifaxCanada | Republic Airline | 2 | 414 mi666 km | 1h 31m |
| NAS NassauBahamas | JetBlue | 1 | 1,250 mi2,012 km | 3h 35m |
| PLS ProvidencialesTurks and Caicos Islands | JetBlue | 1 | 1,421 mi2,287 km | 3h 54m |
| EWB New BedfordUnited States | Cape Air | 1 | 47 mi76 km | 16m |
| SXM Sint MaartenSint Maarten | JetBlue | <1 | 1,739 mi2,799 km | 4h 15m |
| BGI BridgetownBarbados | JetBlue | <1 | 2,132 mi3,431 km | 4h 54m |
| TER Praia da VitóriaPortugal | Azores Airlines | <1 | 2,298 mi3,698 km | 0m |
| POP Puerto PlataDominican Republic | JetBlue | <1 | 1,558 mi2,507 km | 3h 57m |
| HHH Hilton Head IslandUnited States | Republic Airline | <1 | 878 mi1,413 km | 2h 58m |